The relationship between skull acceleration and brain injury is not well understood, in large part because of the challenge of visualizing the brain's mechanical response in vivo. This difficulty also complicates the validation of computational mechanics predictions. Our dynamic magnetic resonance (MR) imaging suggests an important role for the attachments between brain and skull. Here, we present an MRI-based method for identifying the dominant modes of brain displacement relative to the skull during angular acceleration of the head, and apply it to study brain/skull interactions in live volunteers. The approach was to estimate dynamic intracranial displacement fields from a sequence of tagged MR images of the brain and skull, then identify dominant displacement modes using principal component (PC) analysis. After verifying the method through analysis of a simulated 2-D vibrating plate and MR images of a cylindrical gel phantom, the method was applied to show that the dominant mode of brain/skull interaction is one of sliding arrested by brain/skull meninges in a few specific regions.

Original languageEnglish
Title of host publication26th Southern Biomedical Engineering Conference SBEC 2010
Number of pages4
StatePublished - 2010
Event26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States
Duration: Apr 30 2010May 2 2010

Publication series

NameIFMBE Proceedings
Volume32 IFMBE
ISSN (Print)1680-0737


Conference26th Southern Biomedical Engineering Conference, SBEC 2010
Country/TerritoryUnited States
CityCollege Park, MD


  • TBI
  • Tagged MR imaging
  • principal component analysis
  • skull-brain interactions


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