PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

Annabel Quinet, Stephanie Tirman, Jessica Jackson, Saša Šviković, Delphine Lemaçon, Denisse Carvajal-Maldonado, Daniel González-Acosta, Alexandre T. Vessoni, Emily Cybulla, Matthew Wood, Steven Tavis, Luis F.Z. Batista, Juan Méndez, Julian E. Sale, Alessandro Vindigni

Research output: Contribution to journalArticlepeer-review

122 Scopus citations


Reversed replication forks are degraded in BRCA-deficient cells. Quinet et al. show that treatment with multiple cisplatin doses promotes PRIMPOL repriming while suppressing fork reversal and preventing degradation. These studies identify a new function of PRIMPOL in the replication stress response and explain how cells adapt to multiple drug doses.

Original languageEnglish
Pages (from-to)461-474.e9
JournalMolecular cell
Issue number3
StatePublished - Feb 6 2020


  • ATR
  • BRCA
  • DNA damage
  • DNA replication
  • adaptive response
  • replication fork repriming
  • replication fork reversal
  • replication stress response
  • ssDNA gaps


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