PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

Annabel Quinet, Stephanie Tirman, Jessica Jackson, Saša Šviković, Delphine Lemaçon, Denisse Carvajal-Maldonado, Daniel González-Acosta, Alexandre T. Vessoni, Emily Cybulla, Matthew Wood, Steven Tavis, Luis F.Z. Batista, Juan Méndez, Julian E. Sale, Alessandro Vindigni

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Reversed replication forks are degraded in BRCA-deficient cells. Quinet et al. show that treatment with multiple cisplatin doses promotes PRIMPOL repriming while suppressing fork reversal and preventing degradation. These studies identify a new function of PRIMPOL in the replication stress response and explain how cells adapt to multiple drug doses.

Original languageEnglish
Pages (from-to)461-474.e9
JournalMolecular cell
Volume77
Issue number3
DOIs
StatePublished - Feb 6 2020

Keywords

  • ATR
  • BRCA
  • DNA damage
  • DNA replication
  • PRIMPOL
  • adaptive response
  • replication fork repriming
  • replication fork reversal
  • replication stress response
  • ssDNA gaps

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    Quinet, A., Tirman, S., Jackson, J., Šviković, S., Lemaçon, D., Carvajal-Maldonado, D., González-Acosta, D., Vessoni, A. T., Cybulla, E., Wood, M., Tavis, S., Batista, L. F. Z., Méndez, J., Sale, J. E., & Vindigni, A. (2020). PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells. Molecular cell, 77(3), 461-474.e9. https://doi.org/10.1016/j.molcel.2019.10.008