Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease, the etiology of which remains poorly defined. We have reviewed known abnormalities in both the humoral and cell-mediated immunologic systems and describe the abberant expression of class II HLA antigens on biliary epithelial cells. Further work is needed to unite the known findings into a cogent hypothesis, to explain the association of PSC with ulcerative colitis in some patients, and to guide us in developing effective therapy for this, as yet, untreatable disease.
|Number of pages||5|
|Journal||European Journal of Gastroenterology and Hepatology|
|State||Published - Jan 1 1992|