TY - JOUR
T1 - Primary peritoneal epithelioid hemangioendothelioma
AU - Posligua, Lorena
AU - Anatelli, Florencia
AU - Dehner, Louis P.
AU - Pfeifer, John D.
PY - 2006/7
Y1 - 2006/7
N2 - Epithelioid hemangioendothelioma is an uncommon malignant vascular tumor of intermediate grade that occurs in a variety of organs and soft tissues. Diagnosis of epithelioid hemangioendothelioma is often complicated by the rarity of the tumor, and because the tumor shares many morphologic features with other peritoneal neoplasms. This report presents 3 cases of epithelioid hemangioendotheliomas arising as primary tumors of the peritoneum and reviews 7 previously reported cases to establish the demographic, clinical, morphologic, immunohistochemical, and ultrastructural features of this neoplasm. These cases demonstrate that the light microscopic features are very similar to epithelioid hemangioendothelioma arising at more conventional sites, such as the liver, that immunohistochemical analysis provides a reliable approach for confirming or establishing the diagnosis, and that at least one endothelial marker (either CD31, CD34, or factor VIII) should be positive for a definitive diagnosis. This series identifies the characteristics of peritoneal epithelioid hemangioendothelioma that can be reliably used for diagnosis.
AB - Epithelioid hemangioendothelioma is an uncommon malignant vascular tumor of intermediate grade that occurs in a variety of organs and soft tissues. Diagnosis of epithelioid hemangioendothelioma is often complicated by the rarity of the tumor, and because the tumor shares many morphologic features with other peritoneal neoplasms. This report presents 3 cases of epithelioid hemangioendotheliomas arising as primary tumors of the peritoneum and reviews 7 previously reported cases to establish the demographic, clinical, morphologic, immunohistochemical, and ultrastructural features of this neoplasm. These cases demonstrate that the light microscopic features are very similar to epithelioid hemangioendothelioma arising at more conventional sites, such as the liver, that immunohistochemical analysis provides a reliable approach for confirming or establishing the diagnosis, and that at least one endothelial marker (either CD31, CD34, or factor VIII) should be positive for a definitive diagnosis. This series identifies the characteristics of peritoneal epithelioid hemangioendothelioma that can be reliably used for diagnosis.
KW - Epithelioid hemangioendothelioma
KW - Peritoneum
KW - Weibel-Palade body
UR - http://www.scopus.com/inward/record.url?scp=33748996543&partnerID=8YFLogxK
U2 - 10.1177/1066896906290682
DO - 10.1177/1066896906290682
M3 - Review article
C2 - 16959716
AN - SCOPUS:33748996543
SN - 1066-8969
VL - 14
SP - 257
EP - 267
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 3
ER -