Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage

Naoka Murakami; Naohiro Yoshida; Kunihisa Hamano; Hisanori Suzuki; Megumi Miyakawa; Akira Takeshita; Yasuhiro Takeuchi

doi:10.2169/internalmedicine.54.3267

Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage

Naoka Murakami
, Naohiro Yoshida
, Kunihisa Hamano
, Hisanori Suzuki
, Megumi Miyakawa
, Akira Takeshita
, Yasuhiro Takeuchi

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The aldosterone-renin ratio (ARR) is considered to be the most reliable and sensitive screening parameter for primary aldosteronism (PA). However, little is known regarding how stroke influences the ARR. We herein present a case of a 35-year-old man who was ultimately found to have PA after diagnostic challenges. The patient showed an atypical ARR in the acute phase of cerebral hemorrhage. We therefore conclude that the ARR may be inappropriately decreased immediately after stroke in patients with PA, presumably due to sympathetic activation and the effects of medications. When diagnosing PA in patients with stroke, we suggest reevaluating the ARR in the stable phase.

Original language	English
Pages (from-to)	415-420
Number of pages	6
Journal	Internal Medicine
Volume	54
Issue number	4
DOIs	https://doi.org/10.2169/internalmedicine.54.3267
State	Published - 2015

Keywords

Aldosterone-renin ratio
Cerebral hemorrhage
Primary aldosteronism

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10.2169/internalmedicine.54.3267

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title = "Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage",

abstract = "The aldosterone-renin ratio (ARR) is considered to be the most reliable and sensitive screening parameter for primary aldosteronism (PA). However, little is known regarding how stroke influences the ARR. We herein present a case of a 35-year-old man who was ultimately found to have PA after diagnostic challenges. The patient showed an atypical ARR in the acute phase of cerebral hemorrhage. We therefore conclude that the ARR may be inappropriately decreased immediately after stroke in patients with PA, presumably due to sympathetic activation and the effects of medications. When diagnosing PA in patients with stroke, we suggest reevaluating the ARR in the stable phase.",

keywords = "Aldosterone-renin ratio, Cerebral hemorrhage, Primary aldosteronism",

author = "Naoka Murakami and Naohiro Yoshida and Kunihisa Hamano and Hisanori Suzuki and Megumi Miyakawa and Akira Takeshita and Yasuhiro Takeuchi",

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T1 - Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage

AU - Murakami, Naoka

AU - Yoshida, Naohiro

AU - Hamano, Kunihisa

AU - Suzuki, Hisanori

AU - Miyakawa, Megumi

AU - Takeshita, Akira

AU - Takeuchi, Yasuhiro

PY - 2015

Y1 - 2015

N2 - The aldosterone-renin ratio (ARR) is considered to be the most reliable and sensitive screening parameter for primary aldosteronism (PA). However, little is known regarding how stroke influences the ARR. We herein present a case of a 35-year-old man who was ultimately found to have PA after diagnostic challenges. The patient showed an atypical ARR in the acute phase of cerebral hemorrhage. We therefore conclude that the ARR may be inappropriately decreased immediately after stroke in patients with PA, presumably due to sympathetic activation and the effects of medications. When diagnosing PA in patients with stroke, we suggest reevaluating the ARR in the stable phase.

AB - The aldosterone-renin ratio (ARR) is considered to be the most reliable and sensitive screening parameter for primary aldosteronism (PA). However, little is known regarding how stroke influences the ARR. We herein present a case of a 35-year-old man who was ultimately found to have PA after diagnostic challenges. The patient showed an atypical ARR in the acute phase of cerebral hemorrhage. We therefore conclude that the ARR may be inappropriately decreased immediately after stroke in patients with PA, presumably due to sympathetic activation and the effects of medications. When diagnosing PA in patients with stroke, we suggest reevaluating the ARR in the stable phase.

KW - Aldosterone-renin ratio

KW - Cerebral hemorrhage

KW - Primary aldosteronism

UR - https://www.scopus.com/pages/publications/84922903591

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M3 - Article

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AN - SCOPUS:84922903591

SN - 0918-2918

VL - 54

SP - 415

EP - 420

JO - Internal Medicine

JF - Internal Medicine

IS - 4

ER -

Primary aldosteronism presenting with an atypical aldosterone-renin ratio in the acute phase of cerebral hemorrhage

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