Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells

Alan L. Schwartz; Michael R. Hollingdale

doi:10.1016/0166-6851(85)90058-1

Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells

Alan L. Schwartz
, Michael R. Hollingdale

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.

Original language	English
Pages (from-to)	305-311
Number of pages	7
Journal	Molecular and Biochemical Parasitology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0166-6851(85)90058-1
State	Published - Mar 1985

Keywords

Chloroquine
Hepatocyte
Plasmodium berghei sporozoite
Primaquine

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10.1016/0166-6851(85)90058-1

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@article{be6f20afa63348c284317dc273591752,

title = "Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells",

abstract = "The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.",

keywords = "Chloroquine, Hepatocyte, Plasmodium berghei sporozoite, Primaquine",

author = "Schwartz, \{Alan L.\} and Hollingdale, \{Michael R.\}",

note = "Funding Information: The authors thank P. Leland for excellent technical assistance. This study was supported in part by contract DSPE-C-0079 from the Agency for International Development; A.L.S. is a John and George Hartford Foundation Fellow.",

year = "1985",

month = mar,

doi = "10.1016/0166-6851(85)90058-1",

language = "English",

volume = "14",

pages = "305--311",

journal = "Molecular and Biochemical Parasitology",

issn = "0166-6851",

number = "3",

}

TY - JOUR

T1 - Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells

AU - Schwartz, Alan L.

AU - Hollingdale, Michael R.

N1 - Funding Information: The authors thank P. Leland for excellent technical assistance. This study was supported in part by contract DSPE-C-0079 from the Agency for International Development; A.L.S. is a John and George Hartford Foundation Fellow.

PY - 1985/3

Y1 - 1985/3

N2 - The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.

AB - The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.

KW - Chloroquine

KW - Hepatocyte

KW - Plasmodium berghei sporozoite

KW - Primaquine

UR - https://www.scopus.com/pages/publications/0021945477

U2 - 10.1016/0166-6851(85)90058-1

DO - 10.1016/0166-6851(85)90058-1

M3 - Article

C2 - 3887157

AN - SCOPUS:0021945477

SN - 0166-6851

VL - 14

SP - 305

EP - 311

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

IS - 3

ER -

Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells

Abstract

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