TY - JOUR
T1 - Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells
AU - Schwartz, Alan L.
AU - Hollingdale, Michael R.
N1 - Funding Information:
The authors thank P. Leland for excellent technical assistance. This study was supported in part by contract DSPE-C-0079 from the Agency for International Development; A.L.S. is a John and George Hartford Foundation Fellow.
PY - 1985/3
Y1 - 1985/3
N2 - The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.
AB - The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.
KW - Chloroquine
KW - Hepatocyte
KW - Plasmodium berghei sporozoite
KW - Primaquine
UR - http://www.scopus.com/inward/record.url?scp=0021945477&partnerID=8YFLogxK
U2 - 10.1016/0166-6851(85)90058-1
DO - 10.1016/0166-6851(85)90058-1
M3 - Article
C2 - 3887157
AN - SCOPUS:0021945477
SN - 0166-6851
VL - 14
SP - 305
EP - 311
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
IS - 3
ER -