Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells

Alan L. Schwartz, Michael R. Hollingdale

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. While this inhibitory effect of primaquine is rapidly reversible, the precise mechanism responsible for this effect is not presently known.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalMolecular and Biochemical Parasitology
Volume14
Issue number3
DOIs
StatePublished - Mar 1985
Externally publishedYes

Keywords

  • Chloroquine
  • Hepatocyte
  • Plasmodium berghei sporozoite
  • Primaquine

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