Prevention of perioperative infection

Nicholas Fletcher, D'Mitri Sofianos, Marschall Brantling Berkes, William T. Obremskey

Research output: Contribution to journalReview articlepeer-review

153 Scopus citations


▶ Administration of preoperative antibiotics is associated with reduced rates of surgical site infections. ▶ Antibiotics should be continued for no longer than twenty-four hours after elective surgery or surgical treatment of closed fractures. ▶ Chlorhexidine gluconate is superior to povidone-iodine for preoperative antisepsis for the patient and surgeon. ▶ Closed suction drainage is not warranted in elective total joint replacement. It is associated with an increased relative risk of transfusions. Drains left in situ for more than twenty-four hours are at an increased risk for bacterial contamination. ▶ The rate of postoperative infections associated with occlusive dressings is lower than that associated with nonocclusive dressings. ▶ Appropriate management of blood glucose levels, oxygenation, and the temperature of the patient reduces the risk of postoperative infection.

Original languageEnglish
Pages (from-to)1605-1618
Number of pages14
JournalJournal of Bone and Joint Surgery - Series A
Issue number7
StatePublished - Jul 2007


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