Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination

Solomon Langermann, Susan Palaszynski, Michelle Barnhart, Gale Auguste, Jerome S. Pinkner, Jeanne Burlein, Philip Barren, Scott Koenig, Simon Leath, C. Hal Jones, Scott J. Hultgren

Research output: Contribution to journalArticle

440 Scopus citations

Abstract

Virtually all uropathogenic strains of Escherichia coli, the primary cause of cystitis, assemble adhesive surface organelles called type 1 pili that contain the FimH adhesin. Sera from animals vaccinated with candidate FimH vaccines inhibited uropathogenic E. coli from binding to human bladder cells in vitro. Immunization with FimH reduced in vivo colonization of the bladder mucosa by more than 99 percent in a murine cystitis model, and immunoglobulin G to FimH was detected in urinary samples from protected mice. Furthermore, passive systemic administration of immune sera to FimH also resulted in reduced bladder colonization by uropathogenic E. coli. This approach may represent a means of preventing recurrent and acute infections of the urogenital mucosa.

Original languageEnglish
Pages (from-to)607-611
Number of pages5
JournalScience
Volume276
Issue number5312
DOIs
StatePublished - Apr 25 1997

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