Prevention and Treatment of Cancer-Related Infections, Version 3.2024

Lindsey Robert Baden, Sankar Swaminathan, Nikolaos G. Almyroudis, Michael Angarone, Aliyah Baluch, Nicolas Barros, Brian Buss, Stuart Cohen, Brenda Cooper, Augusto Dulanto Chiang, Zeinab El Boghdadly, Kevin Gregg, Hana Hakim, Dora Ho, Fareed Khawaja, Rachael Lee, Francesca Lee, Cathy Logan, Kristen Manley, Ashrit MultaniAnupam Pande, Steven Pergam, Jennifer Pisano, Jennifer Saullo, Mindy Schuster, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Andrea Zimmer, Carly J. Cassara, Rashmi Kumar, Zeenat Diwan

Research output: Contribution to journalArticlepeer-review

Abstract

There is an increased risk of infection in patients with cancer that results in higher morbidity and mortality. Several risk factors can predispose these patients to infectious complications. Some such factors include immunocompromised states like neutropenia, allogeneic hematopoietic cell transplantation, and graft-versus-host disease, while others include immunosuppressive agents like corticosteroids, purine analogs, monoclonal antibodies, and other emerging cancer therapeutics like CAR T-cell therapy. The NCCN Guidelines for the Prevention and Treatment of Cancer-Related Infections address infection concerns that may be observed in these immunocompromised populations and characterize the major pathogens to which patients with cancer are susceptible, with a focus on the prevention, diagnosis, and treatment of major common and opportunistic infections. This paper highlights 2 recently updated sections of the guidelines, namely, infection concerns related to CAR T-cell therapy and antimicrobial prophylaxis recommendations, including vaccination, in patients at high-risk for infections.

Original languageEnglish
Pages (from-to)617-644
Number of pages28
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume22
Issue number9
DOIs
StatePublished - Nov 2024

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