TY - JOUR
T1 - Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus
AU - Boyer, John K.
AU - Thanigaraj, Srihari
AU - Schechtman, Kenneth B.
AU - Pérez, Julio E.
N1 - Funding Information:
This study was supported in part by Grant MO1RR00036 from USPHS, Bethesda, Maryland. Dr. Boyer was funded by NIH Training Grant 2-T32-HL07081, National Institutes of Health, Bethesda, Maryland.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - To determine the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes mellitus, we studied 61 consecutive normotensive patients with type 2 diabetes using conventional Doppler echocardiography at rest (deceleration time, isovolumic relaxation time, early diastolic velocity [E]/peak atrial systolic velocity [A] ratio), and during the Valsalva maneuver. In addition, mitral annular velocity and velocity of flow propagation were assessed in all patients using tissue Doppler imaging (TDI) and color M-mode echocardiography. A standard resting echocardiogram excluded significant valvular disease and stress echocardiography excluded significant coronary artery disease in those with diastolic dysfunction. Diastolic dysfunction was found in 43 of 57 patients (75%) when all of the above echocardiographic techniques were used. TDI detected diastolic dysfunction more often (63%) than any other echocardiographic approach. Thus, the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes without significant coronary artery disease is much higher than previously suspected. TDI markedly improved the echocardiographic detection of diastolic dysfunction in asymptomatic patients with type 2 diabetes.
AB - To determine the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes mellitus, we studied 61 consecutive normotensive patients with type 2 diabetes using conventional Doppler echocardiography at rest (deceleration time, isovolumic relaxation time, early diastolic velocity [E]/peak atrial systolic velocity [A] ratio), and during the Valsalva maneuver. In addition, mitral annular velocity and velocity of flow propagation were assessed in all patients using tissue Doppler imaging (TDI) and color M-mode echocardiography. A standard resting echocardiogram excluded significant valvular disease and stress echocardiography excluded significant coronary artery disease in those with diastolic dysfunction. Diastolic dysfunction was found in 43 of 57 patients (75%) when all of the above echocardiographic techniques were used. TDI detected diastolic dysfunction more often (63%) than any other echocardiographic approach. Thus, the prevalence of left ventricular diastolic dysfunction in asymptomatic, normotensive patients with type 2 diabetes without significant coronary artery disease is much higher than previously suspected. TDI markedly improved the echocardiographic detection of diastolic dysfunction in asymptomatic patients with type 2 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=1842529750&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2003.12.026
DO - 10.1016/j.amjcard.2003.12.026
M3 - Article
C2 - 15050491
AN - SCOPUS:1842529750
SN - 0002-9149
VL - 93
SP - 870
EP - 875
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 7
ER -