Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients

Elizabeth L. Yanik; Sonia Napravnik; Christopher B. Hurt; Ann Dennis; E. Byrd Quinlivan; Joe Sebastian; Joann D. Kuruc; Joseph J. Eron

doi:10.1097/QAI.0b013e3182618f05

Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients

Elizabeth L. Yanik
, Sonia Napravnik
, Christopher B. Hurt
, Ann Dennis
, E. Byrd Quinlivan
, Joe Sebastian
, Joann D. Kuruc
, Joseph J. Eron

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.

Original language	English
Pages (from-to)	258-262
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	61
Issue number	2
DOIs	https://doi.org/10.1097/QAI.0b013e3182618f05
State	Published - Oct 1 2012

Keywords

HIV-1
acute HIV infection
antiretroviral resistance
transmitted drug resistance

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10.1097/QAI.0b013e3182618f05

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title = "Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients",

abstract = "The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-na{\"i}ve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95\% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9\%, whereas prevalence was 8.6\% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95\% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.",

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doi = "10.1097/QAI.0b013e3182618f05",

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T1 - Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients

AU - Yanik, Elizabeth L.

AU - Napravnik, Sonia

AU - Hurt, Christopher B.

AU - Dennis, Ann

AU - Quinlivan, E. Byrd

AU - Sebastian, Joe

AU - Kuruc, Joann D.

AU - Eron, Joseph J.

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N2 - The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.

AB - The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.

KW - HIV-1

KW - acute HIV infection

KW - antiretroviral resistance

KW - transmitted drug resistance

UR - https://www.scopus.com/pages/publications/84866987811

U2 - 10.1097/QAI.0b013e3182618f05

DO - 10.1097/QAI.0b013e3182618f05

M3 - Article

C2 - 22692092

AN - SCOPUS:84866987811

SN - 1525-4135

VL - 61

SP - 258

EP - 262

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

IS - 2

ER -

Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients

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Keywords

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