Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients

Elizabeth L. Yanik, Sonia Napravnik, Christopher B. Hurt, Ann Dennis, E. Byrd Quinlivan, Joe Sebastian, Joann D. Kuruc, Joseph J. Eron

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.

Original languageEnglish
Pages (from-to)258-262
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume61
Issue number2
DOIs
StatePublished - Oct 1 2012

Keywords

  • HIV-1
  • acute HIV infection
  • antiretroviral resistance
  • transmitted drug resistance

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