Prevalence of multiple sclerosis symptoms across lifespan: data from the NARCOMS Registry

Robert J. Fox, Tamar E. Bacon, Eric Chamot, Amber R. Salter, Gary R. Cutter, Jennifer T. Kalina, Ilya Kister

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The North American Research Committee on Multiple Sclerosis is a voluntary patient registry with more than 38,000 registrants as of 2015. In a recent collaborative project, longitudinal data on patient-perceived impairment in 11 domains commonly affected by multiple sclerosis were examined and tabulated as a function of disease duration. The patterns of disability accumulation differed by domain. Certain symptoms (sensory, fatigue) were particularly prevalent early in the disease. Other symptoms (mobility, hand function, fatigue, bowel/bladder dysfunction, spasticity) were progressively more common with longer disease duration. Some symptoms (vision, cognition, sensory, pain, depression) were relatively common early on in multiple sclerosis, but did not appear to be more frequent with longer disease duration. Ongoing research includes studies of the impact of disease-modifying therapy and symptomatic treatment on patient-perceived impairment over the disease course.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalNeurodegenerative disease management
Volume5
Issue number6
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • NARCOMS
  • multiple sclerosis
  • patient registries
  • patient-reported outcomes
  • performance scales

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    Fox, R. J., Bacon, T. E., Chamot, E., Salter, A. R., Cutter, G. R., Kalina, J. T., & Kister, I. (2015). Prevalence of multiple sclerosis symptoms across lifespan: data from the NARCOMS Registry. Neurodegenerative disease management, 5(6), 3-10.