TY - JOUR
T1 - Prevalence of major depressive disorder in patients receiving beta-blocker therapy versus other medications
AU - Carney, Robert M.
AU - Rich, Michael W.
AU - tevelde, Adriaantje
AU - Saini, Jasbir
AU - Clark, Karen
AU - Freedland, Kenneth E.
N1 - Funding Information:
From the Division of Cardiology, Departments Psychiatry and Medicine, Washington University School of Medicine, St. Louis, Missouri. This work was supported in part by a National Research Demonstration Center grant, SCOR grant in lschemic Heart Disease, and National Institutes of Health Grant HL-17464, Bethesda, Maryland. Requests for reprints should be addressed to Dr. Robert M. Carney, Department of Psychiatry, Jewish Hospital, 216 South Kingshighway, St. Louis, Missouri 63110. Manuscript submitted January 30, 1987, and accepted April 22, 1987.
PY - 1987/8
Y1 - 1987/8
N2 - Depression is believed to be a common side effect in patients receiving beta-blocker therapy. However, diagnoses of depression defined by current diagnostic criteria may not be more common in patients receiving beta-blockers than in patients with the same medical disorder receiving other medications. Seventy-seven patients undergoing elective cardiac catheterization for evaluation of chest pain received a semi-structured diagnostic psychiatric interview. Twenty-one percent of the patients receiving beta-blockers and 33 percent of the patients receiving medications other than beta-blockers met the current American Psychiatric Association criteria for major depressive disorder (DSM-III) (p = NS). The mean heart rate and state anxiety scores for patients taking beta-blockers were significantly lower than those measured in patients taking medications other than beta-blockers. No other medical or demographic differences were observed between the two groups. Despite the methodologic limitations of the study, there does not appear to be a difference in the point prevalence of depression between patients receiving beta-blockers and those receiving other medications.
AB - Depression is believed to be a common side effect in patients receiving beta-blocker therapy. However, diagnoses of depression defined by current diagnostic criteria may not be more common in patients receiving beta-blockers than in patients with the same medical disorder receiving other medications. Seventy-seven patients undergoing elective cardiac catheterization for evaluation of chest pain received a semi-structured diagnostic psychiatric interview. Twenty-one percent of the patients receiving beta-blockers and 33 percent of the patients receiving medications other than beta-blockers met the current American Psychiatric Association criteria for major depressive disorder (DSM-III) (p = NS). The mean heart rate and state anxiety scores for patients taking beta-blockers were significantly lower than those measured in patients taking medications other than beta-blockers. No other medical or demographic differences were observed between the two groups. Despite the methodologic limitations of the study, there does not appear to be a difference in the point prevalence of depression between patients receiving beta-blockers and those receiving other medications.
UR - http://www.scopus.com/inward/record.url?scp=0023614091&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(87)90689-9
DO - 10.1016/0002-9343(87)90689-9
M3 - Article
C2 - 2887114
AN - SCOPUS:0023614091
SN - 0002-9343
VL - 83
SP - 223
EP - 226
JO - The American journal of medicine
JF - The American journal of medicine
IS - 2
ER -