Prevalence of antibody to legionella pneumophila in middle-aged and elderly americans

Gregory Storch, Peggy S. Hayes, Dianne L. Hill, William B. Baine

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

An indirect fluorescent antibody (IFA) test was used to establish the background prevalence of antibody to Legionella pneumophila in single serum specimens from 1, 143 persons. The serum specimens had been obtained from volunteers 46 years of age and older who were not acutely ill and who resided in the areas of Atlanta, Georgia; Washington, D. C.; Houston, Texas; and Rochester, New York. The overall prevalence of seroposi-tivity (reciprocal titer, ≥64) was 1.7%. The prevalence of seropositivity did not vary with age, sex, or geographic location. Groups of persons in which the prevalence of reciprocal titers of ≥64 is significantly higher than 1.7% may have unusually great exposure to L. pneumophila. In the population tested, a reciprocal IFA titer of ≥ 64 would have a specificity of 98.3% in the diagnosis of an acute illness as Legionnaires’ disease.

Original languageEnglish
Pages (from-to)784-788
Number of pages5
JournalJournal of Infectious Diseases
Volume140
Issue number5
DOIs
StatePublished - Dec 1979
Externally publishedYes

Fingerprint Dive into the research topics of 'Prevalence of antibody to legionella pneumophila in middle-aged and elderly americans'. Together they form a unique fingerprint.

Cite this