TY - JOUR
T1 - Prevalence, Incidence, and Clearance of Anal High-Risk Human Papillomavirus Infection among HIV-Infected Men in the SUN Study
AU - Patel, Pragna
AU - Bush, Tim
AU - Kojic, Erna Milunka
AU - Conley, Lois
AU - Unger, Elizabeth R.
AU - Darragh, Teresa M.
AU - Henry, Keith
AU - Hammer, John
AU - Escota, Gerome
AU - Palefsky, Joel M.
AU - Brooks, John T.
N1 - Funding Information:
Financial support. This work was supported by Centers for Disease Control and Prevention (contract numbers 200-2002-00610, 200-2002-00611, 200-2002-00612, 200-2002-00613, 200-2007-23633, 200-2007-23634, 200-2007-23635, and 200-2007-23636).
PY - 2018/3/5
Y1 - 2018/3/5
N2 - Background. The natural history of anal human papilloma virus (HPV) infection among human immunodeficiency virus (HIV)-infected men is unknown. Methods. Annually, from 2004 to 2012, we examined baseline prevalence, incidence, and clearance of anal HPV infection at 48 months, and associated factors among HIV-infected men. Results. We examined 403 men who have sex with men (MSM) and 96 men who have sex with women (MSW) (median age 42 years for both, 78% versus 81% prescribed cART, median CD4+ T-lymphocyte cell count 454 versus 379 cells/mm3, and 74% versus 75% had undetectable viral load, respectively). Type 16 prevalence among MSM and MSW was 38% versus 14% (P < .001), and incidence 24% versus 7% (P = .001). Type 18 prevalence was 24% versus 8% (P < .001), and incidence 13% versus 4% (P = .027). Among MSM and MSW, clearance of prevalent HPV 16 and HPV 18 was 31% and 60% (P = .392), and 47% and 25% (P = .297), respectively. Among MSM, receptive anal sex (with or without a condom) was associated with persistent HPV 16 (OR 2.24, P < .001). Conclusions. MSM had higher prevalence and incidence of HPV than MSW, but similar clearance. Receptive anal sex may predict cancer risk among HIV-infected MSM.
AB - Background. The natural history of anal human papilloma virus (HPV) infection among human immunodeficiency virus (HIV)-infected men is unknown. Methods. Annually, from 2004 to 2012, we examined baseline prevalence, incidence, and clearance of anal HPV infection at 48 months, and associated factors among HIV-infected men. Results. We examined 403 men who have sex with men (MSM) and 96 men who have sex with women (MSW) (median age 42 years for both, 78% versus 81% prescribed cART, median CD4+ T-lymphocyte cell count 454 versus 379 cells/mm3, and 74% versus 75% had undetectable viral load, respectively). Type 16 prevalence among MSM and MSW was 38% versus 14% (P < .001), and incidence 24% versus 7% (P = .001). Type 18 prevalence was 24% versus 8% (P < .001), and incidence 13% versus 4% (P = .027). Among MSM and MSW, clearance of prevalent HPV 16 and HPV 18 was 31% and 60% (P = .392), and 47% and 25% (P = .297), respectively. Among MSM, receptive anal sex (with or without a condom) was associated with persistent HPV 16 (OR 2.24, P < .001). Conclusions. MSM had higher prevalence and incidence of HPV than MSW, but similar clearance. Receptive anal sex may predict cancer risk among HIV-infected MSM.
KW - Anal cytology
KW - HIV
KW - HPV
KW - Human immunodeficiency virus
KW - Human papillomavirus
UR - https://www.scopus.com/pages/publications/85042927854
U2 - 10.1093/infdis/jix607
DO - 10.1093/infdis/jix607
M3 - Article
C2 - 29211874
AN - SCOPUS:85042927854
SN - 0022-1899
VL - 217
SP - 953
EP - 963
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -