TY - JOUR
T1 - Prevalence and impact of neuropsychiatric symptoms in normal aging and neurodegenerative syndromes
T2 - A population-based study from Latin America
AU - Rodriguez Salgado, Ana M.
AU - Acosta, Isaac
AU - Kim, Dani J.
AU - Zitser, Jenny
AU - Sosa, Ana Luisa
AU - Acosta, Daisy
AU - Jimenez-Velasquez, Ivonne Z.
AU - Guerra, Mariella
AU - Salas, Aquiles
AU - Valvuerdi, Adolfo
AU - Llibre-Guerra, Juan C.
AU - Jeyachandran, Christine
AU - Contreras, Ricardo López
AU - Hesse, Heike
AU - Tanner, Caroline
AU - Llibre Rodriguez, Juan J.
AU - Prina, Matthew
AU - Llibre-Guerra, Jorge J.
N1 - Funding Information:
This is a secondary analysis of data collected by the 10/66 Dementia Research Group (DRG) ( www.alz.co.uk/1066 ). Principal investigators, data custodians, and responsible parties for research governance in each site are Juan Llibre Rodriguez (Cuba), Daisy Acosta (Dominican Republic), Mariella Guerra (Peru), Aquiles Salas (Venezuela), Ana Luisa Sosa (Mexico), KS Jacob (Vellore, India), Joseph D Williams (Chennai, India), Ivonne Jimenez (Puerto Rico), and Yueqin Huang (China). The 10/66 DRG's research has been funded by the Wellcome Trust Health Consequences of Population Change Program (GR066133, Prevalence phase in Cuba and Brazil; GR080002, Incidence phase in Peru, Mexico, Argentina, Cuba, Dominican Republic, Venezuela, and China), the World Health Organization (India, Dominican Republic, and China), the US Alzheimer's Association (IIRG – 04 – 1286 ‐ Peru, Mexico, and Argentina) and the Puerto Rico State Legislature (Puerto Rico). Secondary data analysis on parkinsonism, dementia, and Parkinson's disease in the 10/66 Latin American countries is supported by the Michael J. Fox Foundation (MJFF‐020770) and the National Institutes of Health—National Institute on Aging (NIH‐NIA; K01AG073526). The content is solely the responsibility of the authors and does not represent the official views of WT, MJFF, or NIH‐NIA. The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Publisher Copyright:
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Neuropsychiatric symptoms (NPSs) are common in neurodegenerative diseases; however, little is known about the prevalence of NPSs in Hispanic populations. METHODS: Using data from community-dwelling participants age 65 years and older enrolled in the 10/66 study (N = 11,768), we aimed to estimate the prevalence of NPSs in Hispanic populations with dementia, parkinsonism, and parkinsonism-dementia (PDD) relative to healthy aging. The Neuropsychiatric Inventory Questionnaire (NPI-Q) was used to assess NPSs. RESULTS: NPSs were highly prevalent in Hispanic populations with neurodegenerative disease; approximately 34.3%, 56.1%, and 61.2% of the participants with parkinsonism, dementia, and PDD exhibited three or more NPSs, respectively. NPSs were the major contributor to caregiver burden. DISCUSSION: Clinicians involved in the care of elderly populations should proactively screen for NPSs, especially in patients with parkinsonism, dementia, and PPD, and develop intervention plans to support families and caregivers. HIGHLIGHTS Neuropsychiatric symptoms (NPSs) are highly prevalent in Hispanic populations with neurodegenerative diseases. In healthy Hispanic populations, NPSs are predominantly mild and not clinically significant. The most common NPSs include depression, sleep disorders, irritability, and agitation. NPSs explain a substantial proportion of the variance in global caregiver burden.
AB - BACKGROUND: Neuropsychiatric symptoms (NPSs) are common in neurodegenerative diseases; however, little is known about the prevalence of NPSs in Hispanic populations. METHODS: Using data from community-dwelling participants age 65 years and older enrolled in the 10/66 study (N = 11,768), we aimed to estimate the prevalence of NPSs in Hispanic populations with dementia, parkinsonism, and parkinsonism-dementia (PDD) relative to healthy aging. The Neuropsychiatric Inventory Questionnaire (NPI-Q) was used to assess NPSs. RESULTS: NPSs were highly prevalent in Hispanic populations with neurodegenerative disease; approximately 34.3%, 56.1%, and 61.2% of the participants with parkinsonism, dementia, and PDD exhibited three or more NPSs, respectively. NPSs were the major contributor to caregiver burden. DISCUSSION: Clinicians involved in the care of elderly populations should proactively screen for NPSs, especially in patients with parkinsonism, dementia, and PPD, and develop intervention plans to support families and caregivers. HIGHLIGHTS Neuropsychiatric symptoms (NPSs) are highly prevalent in Hispanic populations with neurodegenerative diseases. In healthy Hispanic populations, NPSs are predominantly mild and not clinically significant. The most common NPSs include depression, sleep disorders, irritability, and agitation. NPSs explain a substantial proportion of the variance in global caregiver burden.
KW - Hispanic
KW - dementia
KW - neuropsychiatric symptoms
KW - parkinsonism
KW - parkinsonism-dementia
UR - http://www.scopus.com/inward/record.url?scp=85164624143&partnerID=8YFLogxK
U2 - 10.1002/alz.13384
DO - 10.1002/alz.13384
M3 - Article
C2 - 37427840
AN - SCOPUS:85164624143
SN - 1552-5260
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
ER -