Prevalence and impact of neuropsychiatric symptoms in normal aging and neurodegenerative syndromes: A population-based study from Latin America

Ana M. Rodriguez Salgado, Isaac Acosta, Dani J. Kim, Jennifer Zitser, Ana Luisa Sosa, Daisy Acosta, Ivonne Z. Jimenez-Velasquez, Mariella Guerra, Aquiles Salas, Adolfo Valvuerdi, Juan C. Llibre-Guerra, Christine Jeyachandran, Ricardo López Contreras, Heike Hesse, Caroline Tanner, Juan J. Llibre Rodriguez, Matthew Prina, Jorge J. Llibre-Guerra

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

BACKGROUND: Neuropsychiatric symptoms (NPSs) are common in neurodegenerative diseases; however, little is known about the prevalence of NPSs in Hispanic populations. METHODS: Using data from community-dwelling participants age 65 years and older enrolled in the 10/66 study (N = 11,768), we aimed to estimate the prevalence of NPSs in Hispanic populations with dementia, parkinsonism, and parkinsonism-dementia (PDD) relative to healthy aging. The Neuropsychiatric Inventory Questionnaire (NPI-Q) was used to assess NPSs. RESULTS: NPSs were highly prevalent in Hispanic populations with neurodegenerative disease; approximately 34.3%, 56.1%, and 61.2% of the participants with parkinsonism, dementia, and PDD exhibited three or more NPSs, respectively. NPSs were the major contributor to caregiver burden. DISCUSSION: Clinicians involved in the care of elderly populations should proactively screen for NPSs, especially in patients with parkinsonism, dementia, and PPD, and develop intervention plans to support families and caregivers. Highlights Neuropsychiatric symptoms (NPSs) are highly prevalent in Hispanic populations with neurodegenerative diseases. In healthy Hispanic populations, NPSs are predominantly mild and not clinically significant. The most common NPSs include depression, sleep disorders, irritability, and agitation. NPSs explain a substantial proportion of the variance in global caregiver burden.

Original languageEnglish
Pages (from-to)5730-5741
Number of pages12
JournalAlzheimer's and Dementia
Volume19
Issue number12
DOIs
StatePublished - Dec 2023

Keywords

  • Hispanic
  • dementia
  • neuropsychiatric symptoms
  • parkinsonism
  • parkinsonism-dementia

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