Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy

Mary E. Platek; Mary E. Reid; Gregory E. Wilding; Wainwright Jaggernauth; Nestor R. Rigual; Wesley L. Hicks; Saurin R. Popat; Graham W. Warren; Maureen Sullivan; Wade L. Thorstad; Mohamed K. Khan; Thom R. Loree; Anurag K. Singh

doi:10.1002/hed.21640

Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy

Mary E. Platek, Mary E. Reid, Gregory E. Wilding, Wainwright Jaggernauth, Nestor R. Rigual, Wesley L. Hicks, Saurin R. Popat, Graham W. Warren, Maureen Sullivan, Wade L. Thorstad, Mohamed K. Khan, Thom R. Loree, Anurag K. Singh

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Abstract

Background This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity-modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure. Results Fifteen of 78 patients (19%) experienced locoregional failure. Median follow-up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) (p <.01), pretreatment hemoglobin (p =.04), and treatment duration (p <.01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW (p =.04) and treatment time (p <.01) remained statistically significant. Conclusions Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further.

Original language	English
Pages (from-to)	1561-1568
Number of pages	8
Journal	Head and Neck
Volume	33
Issue number	11
DOIs	https://doi.org/10.1002/hed.21640
State	Published - Nov 2011

Keywords

concurrent chemoradiation therapy
ideal body weight
nutrition
percutaneous endoscopic gastrostomy tube
squamous cell carcinoma of the head and neck

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Platek, M. E., Reid, M. E., Wilding, G. E., Jaggernauth, W., Rigual, N. R., Hicks, W. L., Popat, S. R., Warren, G. W., Sullivan, M., Thorstad, W. L., Khan, M. K., Loree, T. R., & Singh, A. K. (2011). Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy. Head and Neck, 33(11), 1561-1568. https://doi.org/10.1002/hed.21640

@article{fe101291e7d740ecbf1dc347ae6806be,

title = "Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy",

abstract = "Background This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity-modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure. Results Fifteen of 78 patients (19%) experienced locoregional failure. Median follow-up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) (p <.01), pretreatment hemoglobin (p =.04), and treatment duration (p <.01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW (p =.04) and treatment time (p <.01) remained statistically significant. Conclusions Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further.",

keywords = "concurrent chemoradiation therapy, ideal body weight, nutrition, percutaneous endoscopic gastrostomy tube, squamous cell carcinoma of the head and neck",

author = "Platek, {Mary E.} and Reid, {Mary E.} and Wilding, {Gregory E.} and Wainwright Jaggernauth and Rigual, {Nestor R.} and Hicks, {Wesley L.} and Popat, {Saurin R.} and Warren, {Graham W.} and Maureen Sullivan and Thorstad, {Wade L.} and Khan, {Mohamed K.} and Loree, {Thom R.} and Singh, {Anurag K.}",

year = "2011",

month = nov,

doi = "10.1002/hed.21640",

language = "English",

volume = "33",

pages = "1561--1568",

journal = "Head and Neck",

issn = "1043-3074",

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Platek, ME, Reid, ME, Wilding, GE, Jaggernauth, W, Rigual, NR, Hicks, WL, Popat, SR, Warren, GW, Sullivan, M, Thorstad, WL, Khan, MK, Loree, TR & Singh, AK 2011, 'Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy', Head and Neck, vol. 33, no. 11, pp. 1561-1568. https://doi.org/10.1002/hed.21640

TY - JOUR

T1 - Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy

AU - Platek, Mary E.

AU - Reid, Mary E.

AU - Wilding, Gregory E.

AU - Jaggernauth, Wainwright

AU - Rigual, Nestor R.

AU - Hicks, Wesley L.

AU - Popat, Saurin R.

AU - Warren, Graham W.

AU - Sullivan, Maureen

AU - Thorstad, Wade L.

AU - Khan, Mohamed K.

AU - Loree, Thom R.

AU - Singh, Anurag K.

PY - 2011/11

Y1 - 2011/11

N2 - Background This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity-modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure. Results Fifteen of 78 patients (19%) experienced locoregional failure. Median follow-up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) (p <.01), pretreatment hemoglobin (p =.04), and treatment duration (p <.01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW (p =.04) and treatment time (p <.01) remained statistically significant. Conclusions Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further.

AB - Background This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity-modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure. Results Fifteen of 78 patients (19%) experienced locoregional failure. Median follow-up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) (p <.01), pretreatment hemoglobin (p =.04), and treatment duration (p <.01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW (p =.04) and treatment time (p <.01) remained statistically significant. Conclusions Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further.

KW - concurrent chemoradiation therapy

KW - ideal body weight

KW - nutrition

KW - percutaneous endoscopic gastrostomy tube

KW - squamous cell carcinoma of the head and neck

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SN - 1043-3074

VL - 33

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JO - Head and Neck

JF - Head and Neck

IS - 11

ER -

Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy

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