Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging

John M. Floberg; Todd A. DeWees; Re I. Chin; Adam A. Garsa; Farrokh Dehdashti; Brian Nussenbaum; Peter J. Oppelt; Douglas R. Adkins; Hiram A. Gay; Wade L. Thorstad

doi:10.1002/hed.25337

Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging

John M. Floberg, Todd A. DeWees, Re I. Chin, Adam A. Garsa, Farrokh Dehdashti, Brian Nussenbaum, Peter J. Oppelt, Douglas R. Adkins, Hiram A. Gay, Wade L. Thorstad

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12 Scopus citations

Abstract

Background: This study evaluates the prognostic significance of ¹⁸F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm³) was prognostic for FFR (P =.0002), FFDM (P =.001), and OS (P <.0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P =.03), and stage III patients (P =.04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

Original language	English
Pages (from-to)	2280-2287
Number of pages	8
Journal	Head and Neck
Volume	40
Issue number	10
DOIs	https://doi.org/10.1002/hed.25337
State	Published - Oct 2018

Keywords

human papillomavirus (HPV)
metabolic tumor volume
oropharyngeal cancer
positron emission tomography
prognostic markers

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10.1002/hed.25337

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@article{5af4cea043a3447d8854809044e7fac9,

title = "Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging",

abstract = "Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P =.0002), FFDM (P =.001), and OS (P <.0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P =.03), and stage III patients (P =.04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.",

keywords = "human papillomavirus (HPV), metabolic tumor volume, oropharyngeal cancer, positron emission tomography, prognostic markers",

author = "Floberg, {John M.} and DeWees, {Todd A.} and Chin, {Re I.} and Garsa, {Adam A.} and Farrokh Dehdashti and Brian Nussenbaum and Oppelt, {Peter J.} and Adkins, {Douglas R.} and Gay, {Hiram A.} and Thorstad, {Wade L.}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

month = oct,

doi = "10.1002/hed.25337",

language = "English",

volume = "40",

pages = "2280--2287",

journal = "Head and Neck",

issn = "1043-3074",

number = "10",

}

TY - JOUR

T1 - Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging

AU - Floberg, John M.

AU - DeWees, Todd A.

AU - Chin, Re I.

AU - Garsa, Adam A.

AU - Dehdashti, Farrokh

AU - Nussenbaum, Brian

AU - Oppelt, Peter J.

AU - Adkins, Douglas R.

AU - Gay, Hiram A.

AU - Thorstad, Wade L.

PY - 2018/10

Y1 - 2018/10

N2 - Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P =.0002), FFDM (P =.001), and OS (P <.0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P =.03), and stage III patients (P =.04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

AB - Background: This study evaluates the prognostic significance of 18F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging. Methods: We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression. Results: In this 153-patient cohort, stratifying by the optimum MTV (24 cm3) was prognostic for FFR (P =.0002), FFDM (P =.001), and OS (P <.0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P =.03), and stage III patients (P =.04). On multivariate analysis only MTV was a significant factor for OS. Conclusion: Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

KW - human papillomavirus (HPV)

KW - metabolic tumor volume

KW - oropharyngeal cancer

KW - positron emission tomography

KW - prognostic markers

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U2 - 10.1002/hed.25337

DO - 10.1002/hed.25337

M3 - Article

C2 - 30051553

AN - SCOPUS:85051133796

SN - 1043-3074

VL - 40

SP - 2280

EP - 2287

JO - Head and Neck

JF - Head and Neck

IS - 10

ER -

Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging

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