TY - JOUR
T1 - Pretreatment leukocytosis is an indicator of poor prognosis in patients with cervical cancer
AU - Mabuchi, Seiji
AU - Matsumoto, Yuri
AU - Isohashi, Fumiaki
AU - Yoshioka, Yasuo
AU - Ohashi, Hiroshi
AU - Morii, Eiichi
AU - Hamasaki, Toshimitsu
AU - Aozasa, Katsuyuki
AU - Mutch, David G.
AU - Kimura, Tadashi
N1 - Funding Information:
Grant support: This work was supported by Grant-in-aid for Young Scientists, No 21791554 from the Ministry of Education, Culture, Sports, Science and Technology of Japan .
PY - 2011/7
Y1 - 2011/7
N2 - Objectives: The aim of this study was to investigate the prognostic value of pretreatment leukocytosis in patients with cervical cancer in relation to well-established conventional risk factors. Methods: The baseline characteristics and outcome data from 536 patients treated for cervical cancer between 1996 April to 2007 March were collected and reviewed. Cox proportional hazards regression model was used to identify independent prognostic factors for overall survival. Subsequently, the prognostic significance of pretreatment WBC count was prospectively investigated in 156 patients newly diagnosed cervical cancer from 2007 April to 2010 March. Results: In a retrospective analysis, patients with leukocytosis (WBC ≥ 10,000/μl) showed significantly higher treatment failure rate (P < 0.0001) and shorter OS (P < 0.0001) than the patients without leukocytosis. Tumors from patients with leukocytosis showed significantly stronger immunoreactivity for G-CSF than those obtained from patients without leukocytosis. Multivariate analyses revealed that clinical stage, tumor diameter, histology, and elevated WBC count (≥ 10,000/μl) were significant prognostic factors in terms of overall survival. In a prospective investigation, patients with leukocytosis showed significantly higher treatment failure rate (P < 0.0001), shorter PFS (P < 0.0001), and higher serum G-CSF concentrations (p = 0.001) than the patients without leukocytosis. Multivariate analyses revealed that clinical stage, tumor diameter, and elevated WBC count were significant prognostic factors in terms of PFS. Conclusion: Pretreatment leukocytosis is an independent prognostic factor in patients with cervical cancer. Our finding can be used to identify patients with poor prognosis and to design future tailored clinical trials.
AB - Objectives: The aim of this study was to investigate the prognostic value of pretreatment leukocytosis in patients with cervical cancer in relation to well-established conventional risk factors. Methods: The baseline characteristics and outcome data from 536 patients treated for cervical cancer between 1996 April to 2007 March were collected and reviewed. Cox proportional hazards regression model was used to identify independent prognostic factors for overall survival. Subsequently, the prognostic significance of pretreatment WBC count was prospectively investigated in 156 patients newly diagnosed cervical cancer from 2007 April to 2010 March. Results: In a retrospective analysis, patients with leukocytosis (WBC ≥ 10,000/μl) showed significantly higher treatment failure rate (P < 0.0001) and shorter OS (P < 0.0001) than the patients without leukocytosis. Tumors from patients with leukocytosis showed significantly stronger immunoreactivity for G-CSF than those obtained from patients without leukocytosis. Multivariate analyses revealed that clinical stage, tumor diameter, histology, and elevated WBC count (≥ 10,000/μl) were significant prognostic factors in terms of overall survival. In a prospective investigation, patients with leukocytosis showed significantly higher treatment failure rate (P < 0.0001), shorter PFS (P < 0.0001), and higher serum G-CSF concentrations (p = 0.001) than the patients without leukocytosis. Multivariate analyses revealed that clinical stage, tumor diameter, and elevated WBC count were significant prognostic factors in terms of PFS. Conclusion: Pretreatment leukocytosis is an independent prognostic factor in patients with cervical cancer. Our finding can be used to identify patients with poor prognosis and to design future tailored clinical trials.
KW - Cervical cancer
KW - G-CSF
KW - Leukocytosis
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=79957721994&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2011.03.037
DO - 10.1016/j.ygyno.2011.03.037
M3 - Article
C2 - 21514632
AN - SCOPUS:79957721994
SN - 0090-8258
VL - 122
SP - 25
EP - 32
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -