Preterm premature rupture of the fetal membranes: Current concepts

S. K. Srinivas; G. A. Macones

Preterm premature rupture of the fetal membranes: Current concepts

S. K. Srinivas, G. A. Macones

Division of Clinical Research

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Preterm birth and preterm premature rupture of membranes (PPROM) are common causes of perinatal morbidity and mortality. Fetal membrane integrity is regulated partially by collagenases and inhibitors. A number of genetic polymorphisms with genes related to infection, inflammation and collagen degradation have been identified and studies as risk factors for PPROM. This manuscript reviews the state of the science on the pathophysiology of PPROM and possible genetic influences.

Original language	English
Pages (from-to)	389-396
Number of pages	8
Journal	Minerva Ginecologica
Volume	57
Issue number	4
State	Published - Aug 1 2005

Keywords

Amniotic membranes
Epidemiology
Genetics
Preterm premature rupture

Cite this

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title = "Preterm premature rupture of the fetal membranes: Current concepts",

abstract = "Preterm birth and preterm premature rupture of membranes (PPROM) are common causes of perinatal morbidity and mortality. Fetal membrane integrity is regulated partially by collagenases and inhibitors. A number of genetic polymorphisms with genes related to infection, inflammation and collagen degradation have been identified and studies as risk factors for PPROM. This manuscript reviews the state of the science on the pathophysiology of PPROM and possible genetic influences.",

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AU - Srinivas, S. K.

AU - Macones, G. A.

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N2 - Preterm birth and preterm premature rupture of membranes (PPROM) are common causes of perinatal morbidity and mortality. Fetal membrane integrity is regulated partially by collagenases and inhibitors. A number of genetic polymorphisms with genes related to infection, inflammation and collagen degradation have been identified and studies as risk factors for PPROM. This manuscript reviews the state of the science on the pathophysiology of PPROM and possible genetic influences.

AB - Preterm birth and preterm premature rupture of membranes (PPROM) are common causes of perinatal morbidity and mortality. Fetal membrane integrity is regulated partially by collagenases and inhibitors. A number of genetic polymorphisms with genes related to infection, inflammation and collagen degradation have been identified and studies as risk factors for PPROM. This manuscript reviews the state of the science on the pathophysiology of PPROM and possible genetic influences.

KW - Amniotic membranes

KW - Epidemiology

KW - Genetics

KW - Preterm premature rupture

UR - http://www.scopus.com/inward/record.url?scp=27144435526&partnerID=8YFLogxK

M3 - Review article

C2 - 16170284

AN - SCOPUS:27144435526

SN - 0026-4784

VL - 57

SP - 389

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JO - Minerva Ginecologica

JF - Minerva Ginecologica

IS - 4

ER -

Preterm premature rupture of the fetal membranes: Current concepts

Abstract

Keywords

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