Preterm premature rupture of the fetal membranes: Current concepts

S. K. Srinivas, G. A. Macones

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Preterm birth and preterm premature rupture of membranes (PPROM) are common causes of perinatal morbidity and mortality. Fetal membrane integrity is regulated partially by collagenases and inhibitors. A number of genetic polymorphisms with genes related to infection, inflammation and collagen degradation have been identified and studies as risk factors for PPROM. This manuscript reviews the state of the science on the pathophysiology of PPROM and possible genetic influences.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalMinerva Ginecologica
Issue number4
StatePublished - Aug 1 2005


  • Amniotic membranes
  • Epidemiology
  • Genetics
  • Preterm premature rupture


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