TY - JOUR
T1 - Presynaptic Inhibition Modulates Spillover, Creating Distinct Dynamic Response Ranges of Sensory Output
AU - Sagdullaev, Botir T.
AU - McCall, Maureen A.
AU - Lukasiewicz, Peter D.
N1 - Funding Information:
This work was supported by NIH grants EY08922 (P.D.L.), EY014701 (M.A.M.), and EY02687 (W.U. Dept. Ophthalmology), Research to Prevent Blindness, and The M. Bauer Foundation. The authors thank Steven Mennerick, Jeffrey Diamond, Rachel Wong, and members of the Lukasiewicz and McCall laboratories for comments on the manuscript.
PY - 2006/6
Y1 - 2006/6
N2 - Sensory information is thought to be modulated by presynaptic inhibition. Although this form of inhibition is a well-studied phenomenon, it is still unclear what role it plays in shaping sensory signals in intact circuits. By visually stimulating the retinas of transgenic mice lacking GABAc receptor-mediated presynaptic inhibition, we found that this inhibition regulated the dynamic range of ganglion cell (GC) output to the brain. Presynaptic inhibition acted differentially upon two major retinal pathways; its elimination affected GC responses to increments, but not decrements, in light intensity across the visual scene. The GC dynamic response ranges were different because presynaptic inhibition limited glutamate release from ON, but not OFF, bipolar cells, which modulate the extent of glutamate spillover and activation of perisynaptic NMDA receptors at ON GCs. Our results establish a role for presynaptic inhibitory control of spillover in determining sensory output in the CNS.
AB - Sensory information is thought to be modulated by presynaptic inhibition. Although this form of inhibition is a well-studied phenomenon, it is still unclear what role it plays in shaping sensory signals in intact circuits. By visually stimulating the retinas of transgenic mice lacking GABAc receptor-mediated presynaptic inhibition, we found that this inhibition regulated the dynamic range of ganglion cell (GC) output to the brain. Presynaptic inhibition acted differentially upon two major retinal pathways; its elimination affected GC responses to increments, but not decrements, in light intensity across the visual scene. The GC dynamic response ranges were different because presynaptic inhibition limited glutamate release from ON, but not OFF, bipolar cells, which modulate the extent of glutamate spillover and activation of perisynaptic NMDA receptors at ON GCs. Our results establish a role for presynaptic inhibitory control of spillover in determining sensory output in the CNS.
KW - PROTEINS
KW - SIGNALING
KW - SYSNEURO
UR - http://www.scopus.com/inward/record.url?scp=33744929645&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2006.05.015
DO - 10.1016/j.neuron.2006.05.015
M3 - Article
C2 - 16772173
AN - SCOPUS:33744929645
SN - 0896-6273
VL - 50
SP - 923
EP - 935
JO - Neuron
JF - Neuron
IS - 6
ER -