Presentation and effectiveness of early treatment of type 2 diabetes in youth: Lessons from the TODAY study

for the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study Group

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47 Scopus citations

Abstract

Objective: The objectives were to (i) describe the characteristics of a large ethnically/racially and geographically diverse population of adolescents with recent-onset type 2 diabetes (T2D), and (ii) assess the effects of short-term diabetes education and treatment with metformin on clinical and biochemical parameters in this cohort. Research design and methods: Descriptive characteristics were determined for subjects screened for Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) who met criteria for diagnosis of T2D (n=1092). Changes in clinical and biochemical parameters were determined for those who completed at least 8wk of the run-in phase of the trial, which included standardized diabetes education and treatment with metformin. Further analysis determined whether these changes differed according to the treatment at screening. Main outcome measures: Demographic, biochemical measurements, and anthropometrics at screening and changes over 8wk of run-in were the outcome measures. Results: Subjects screened for TODAY had a median age of 14yr and median hemoglobin A1c (HbA1c) of 6.9% (52mM/M), 2/3 were female, and ethnic/racial minorities were overrepresented. Dyslipidemia and hypertension were common comorbidities. During run-in, HbA1c, body mass index, low-density lipoprotein cholesterol, triglycerides, and blood pressure significantly improved. Nearly all participants on insulin therapy at screening were able to attain target HbA1c following insulin discontinuation. Conclusions: Treatment with metformin and diabetes education provided short-term improvements in glycemic control and cardiometabolic risk factors in a large adolescent T2D cohort. Nearly all insulin-treated youth could be successfully weaned off insulin with continued improvement in glycemic control.

Original languageEnglish
Pages (from-to)212-221
Number of pages10
JournalPediatric Diabetes
Volume17
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • Diabetes education
  • Insulin therapy
  • Metformin

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