TY - JOUR
T1 - Present and future technology for simultaneous superficial thermoradiotherapy of breast cancer
AU - Moros, Eduardo G.
AU - Peagaricano, Jose
AU - Novk, Petr
AU - Straube, William L.
AU - Myerson, Robert J.
N1 - Funding Information:
Declaration of interest: The work reviewed in this paper was supported by NIH Grants CA 63121 and CA 71638, and by a grant from the Whitaker Foundation. We gratefully acknowledge partial support from the Central Arkansas Radiation Therapy Institute (CARTI) and a Medical Research Endowment pilot award from College of Medicine of the University of Arkansas for Medical Sciences, Little Rock.
PY - 2010/10
Y1 - 2010/10
N2 - This paper reviews systems and techniques to deliver simultaneous thermoradiotherapy of breast cancer. It first covers the clinical implementation of simultaneous delivery of superficial (microwave or ultrasound) hyperthermia and external photon beam radiotherapy, first using a Cobalt-60 teletherapy unit and later medical linear accelerators. The parallel development and related studies of the Scanning Ultrasound Reflector Linear Arrays System (SURLAS), an advanced system specifically designed and developed for simultaneous thermoradiotherapy, follows. The performance characteristics of the SURLAS are reviewed and power limitation problems at high acoustic frequencies (>3 MHz) are discussed along with potential solutions. Next, the feasibility of simultaneous SURLAS hyperthermia and intensity modulated radiation therapy/image-guided radiotherapy (IMRT/IGRT) is established based on published and newly presented studies. Finally, based on the encouraging clinical results thus far, it is concluded that new trials employing the latest technologies are warranted along with further developments in treatment planning.
AB - This paper reviews systems and techniques to deliver simultaneous thermoradiotherapy of breast cancer. It first covers the clinical implementation of simultaneous delivery of superficial (microwave or ultrasound) hyperthermia and external photon beam radiotherapy, first using a Cobalt-60 teletherapy unit and later medical linear accelerators. The parallel development and related studies of the Scanning Ultrasound Reflector Linear Arrays System (SURLAS), an advanced system specifically designed and developed for simultaneous thermoradiotherapy, follows. The performance characteristics of the SURLAS are reviewed and power limitation problems at high acoustic frequencies (>3 MHz) are discussed along with potential solutions. Next, the feasibility of simultaneous SURLAS hyperthermia and intensity modulated radiation therapy/image-guided radiotherapy (IMRT/IGRT) is established based on published and newly presented studies. Finally, based on the encouraging clinical results thus far, it is concluded that new trials employing the latest technologies are warranted along with further developments in treatment planning.
KW - Breast cancer
KW - Chest wall recurrences
KW - Hyperthermia
KW - Intensity modulated radiation therapy
KW - Simultaneous thermoradiotherapy
KW - Thermal radiosensitization
UR - http://www.scopus.com/inward/record.url?scp=77956923241&partnerID=8YFLogxK
U2 - 10.3109/02656736.2010.493915
DO - 10.3109/02656736.2010.493915
M3 - Review article
C2 - 20849263
AN - SCOPUS:77956923241
SN - 0265-6736
VL - 26
SP - 699
EP - 709
JO - International Journal of Hyperthermia
JF - International Journal of Hyperthermia
IS - 7
ER -