Presenilin: RIP and beyond

Matthew R. Hass, Chihiro Sato, Raphael Kopan, Guojun Zhao

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations


Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through γ-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of β-catenin function, protein trafficking, calcium regulation, and apoptosis.

Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalSeminars in Cell and Developmental Biology
Issue number2
StatePublished - Apr 2009


  • Apoptosis
  • Calcium
  • Presenilin
  • Regulated intramembrane proteolysis
  • β-Catenin


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