Presenilin: RIP and beyond

Matthew R. Hass; Chihiro Sato; Raphael Kopan; Guojun Zhao

doi:10.1016/j.semcdb.2008.11.014

Presenilin: RIP and beyond

Matthew R. Hass, Chihiro Sato, Raphael Kopan, Guojun Zhao

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through γ-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of β-catenin function, protein trafficking, calcium regulation, and apoptosis.

Original language	English
Pages (from-to)	201-210
Number of pages	10
Journal	Seminars in Cell and Developmental Biology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.semcdb.2008.11.014
State	Published - Apr 2009

Keywords

Apoptosis
Calcium
Presenilin
Regulated intramembrane proteolysis
β-Catenin

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10.1016/j.semcdb.2008.11.014

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title = "Presenilin: RIP and beyond",

abstract = "Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through γ-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of β-catenin function, protein trafficking, calcium regulation, and apoptosis.",

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T2 - RIP and beyond

AU - Hass, Matthew R.

AU - Sato, Chihiro

AU - Kopan, Raphael

AU - Zhao, Guojun

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AB - Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through γ-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of β-catenin function, protein trafficking, calcium regulation, and apoptosis.

KW - Apoptosis

KW - Calcium

KW - Presenilin

KW - Regulated intramembrane proteolysis

KW - β-Catenin

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SN - 1084-9521

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EP - 210

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 2

ER -

Presenilin: RIP and beyond

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Keywords

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