TY - JOUR
T1 - Preschool sleep and depression interact to predict gray matter volume trajectories across late childhood to adolescence
AU - Hoyniak, Caroline
AU - Whalen, Diana J.
AU - Tillman, Rebecca
AU - Luby, Joan L.
AU - Barch, Deanna M.
N1 - Funding Information:
All phases of this study were supported by a National Institutes of Health ( NIH ) grant, R01 MH064769-06A1 . Dr. Hoyniak’s work was supported by NIH grant: T32 MH100019 (PI’s: Barch and Luby) and K23 MH127305-01 (PI: Hoyniak). Dr. Whalen’s work was supported by NIH grants: L30 MH108015 (PI: Whalen) and K23 MH118426 (PI: Whalen).
Publisher Copyright:
© 2021
PY - 2022/2
Y1 - 2022/2
N2 - There is a close relationship between sleep and depression, and certain maladaptive outcomes of sleep problems may only be apparent in individuals with heightened levels of depression. In a sample enriched for preschool depression, we examined how sleep and depression in early childhood interact to predict later trajectories of gray matter volume. Participants (N = 161) were recruited and assessed during preschool (ages 3–6 years) and were later assessed with five waves of structural brain imaging, spanning from late childhood to adolescence. Sleep and depression were assessed using a semi-structured parent interview when the children were preschool-aged, and total gray matter volume was calculated at each scan wave. Although sleep disturbances alone did not predict gray matter volume/trajectories, preschool sleep and depression symptoms interacted to predict later total gray matter volume and the trajectory of decline in total gray matter volume. Sleep disturbances in the form of longer sleep onset latencies, increased irregularity in the child's sleep schedule, and higher levels of daytime sleepiness in early childhood were all found to interact with early childhood depression severity to predict later trajectories of cortical gray matter volume. Findings provide evidence of the interactive effects of preschool sleep and depression symptoms on later neurodevelopment.
AB - There is a close relationship between sleep and depression, and certain maladaptive outcomes of sleep problems may only be apparent in individuals with heightened levels of depression. In a sample enriched for preschool depression, we examined how sleep and depression in early childhood interact to predict later trajectories of gray matter volume. Participants (N = 161) were recruited and assessed during preschool (ages 3–6 years) and were later assessed with five waves of structural brain imaging, spanning from late childhood to adolescence. Sleep and depression were assessed using a semi-structured parent interview when the children were preschool-aged, and total gray matter volume was calculated at each scan wave. Although sleep disturbances alone did not predict gray matter volume/trajectories, preschool sleep and depression symptoms interacted to predict later total gray matter volume and the trajectory of decline in total gray matter volume. Sleep disturbances in the form of longer sleep onset latencies, increased irregularity in the child's sleep schedule, and higher levels of daytime sleepiness in early childhood were all found to interact with early childhood depression severity to predict later trajectories of cortical gray matter volume. Findings provide evidence of the interactive effects of preschool sleep and depression symptoms on later neurodevelopment.
KW - Early childhood sleep
KW - Gray matter volume
KW - Longitudinal
KW - Preschool depression
UR - http://www.scopus.com/inward/record.url?scp=85121333171&partnerID=8YFLogxK
U2 - 10.1016/j.dcn.2021.101053
DO - 10.1016/j.dcn.2021.101053
M3 - Article
C2 - 34933170
AN - SCOPUS:85121333171
VL - 53
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
SN - 1878-9293
M1 - 101053
ER -