TY - CHAP
T1 - Prepartum depressive symptoms, C-reactive protein and tryptophan levels
AU - Scrandis, Debra A.
AU - Langenberg, Patricia
AU - Tonelli, Leonardo H.
AU - Sheikh, Tehmina M.
AU - Manogura, Anita C.
AU - Alberico, Laura A.
AU - Hermanstyne, Tracey
AU - Fuchs, Dietmar
AU - Mighty, Hugh
AU - Hasday, Jeffrey D.
AU - Boteva, Kalina
AU - Postolache, Teodor T.
N1 - Publisher Copyright:
© 2011 by Nova Science Publishers, Inc.
PY - 2013/2/4
Y1 - 2013/2/4
N2 - Prepartum and postpartum depression have negative, and sometimes devastating, effects on women and their families. As inflammatory processes are related to depression in general, we hypothesized that inflammatory perturbations, prepartum and postpartum, contribute to triggering and worsening of symptoms of peripartum depression. We conducted a longitudinal preliminary study on 27 women at high risk for developing postpartum depression at three time points: 35-38 weeks gestation, 1-5 days postpartum, and 5-6 weeks postpartum. Depressive symptoms were measured with the SIGH-SAD scale. Serum C-reactive protein and interleukin-6, both markers of inflammation, as well as tryptophan, kynurenine, and the kynurenine/tryptophan ratio, as consequences of inflammation and pathophysiological steps towards depression, were measured at each time point. C-reactive protein levels were found to be positively related to atypical and total depression scores in the prepartum period and with atypical depression scores in the early postpartum period. Tryptophan was found to be negatively associated with total depression scores in the prepartum, as well. These findings warrant further investigation that could lead to novel interventions to decrease poor outcomes from peripartum depression.
AB - Prepartum and postpartum depression have negative, and sometimes devastating, effects on women and their families. As inflammatory processes are related to depression in general, we hypothesized that inflammatory perturbations, prepartum and postpartum, contribute to triggering and worsening of symptoms of peripartum depression. We conducted a longitudinal preliminary study on 27 women at high risk for developing postpartum depression at three time points: 35-38 weeks gestation, 1-5 days postpartum, and 5-6 weeks postpartum. Depressive symptoms were measured with the SIGH-SAD scale. Serum C-reactive protein and interleukin-6, both markers of inflammation, as well as tryptophan, kynurenine, and the kynurenine/tryptophan ratio, as consequences of inflammation and pathophysiological steps towards depression, were measured at each time point. C-reactive protein levels were found to be positively related to atypical and total depression scores in the prepartum period and with atypical depression scores in the early postpartum period. Tryptophan was found to be negatively associated with total depression scores in the prepartum, as well. These findings warrant further investigation that could lead to novel interventions to decrease poor outcomes from peripartum depression.
UR - http://www.scopus.com/inward/record.url?scp=85108934150&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:85108934150
SP - 143
EP - 153
BT - Environment, Mood Disorders and Suicide
PB - Nova Science Publishers, Inc.
ER -