Preparation of nucleoside 3',5'-cyclic phosphates via phosphotriester intermediates

Jacques H. Van Boom, Peter M.J. Burgers, Peter Van Deursen, Colin B. Reese

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Several ribonucleoside 3',5'-cyclic phosphates (7b) have been prepared in good yields by the action of base on the corresponding 2'-protected 3'-diphenyl phosphates (5); thymidine 3',5'-cyclic phosphate (7; R = H, B = thymine-1) has similarly been prepared from both thymidine 3'- and 5'-diphenyl phosphates (8a and 8b).

Original languageEnglish
Pages (from-to)618-619
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number15
StatePublished - 1974


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