Preparation of Degradable Polymeric Nanoparticles with Various Sizes and Surface Charges from Polycarbonate Block Copolymers

Gyu Seong Heo, Sangho Cho, Karen L. Wooley

Research output: Contribution to journalArticlepeer-review

Abstract

ABA-type polycarbonate block copolymers with pendant vinyl ether and benzyl functionalities were synthesized by sequential ring-opening polymerization of functional cyclic carbonate monomers using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organobase catalyst. The vinyl ether moieties on the resulting block copolymers were readily conjugated with 3-mercaptopropionic acid, cysteamine hydrochloride, and L-cysteine hydrochloride monohydrate through thiol-ene “click” reactions, yielding anionic, cationic, and zwitterionic self-assembled nanoparticles, respectively, in corresponding buffers. The effect of pH on the size and surface charge of nanoparticles were examined. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)1173-1178
Number of pages6
JournalMacromolecular Research
Volume27
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • charged micelles
  • click chemistry
  • degradable polymeric nanoparticles
  • polycarbonates

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