TY - JOUR
T1 - Preparation of Degradable Polymeric Nanoparticles with Various Sizes and Surface Charges from Polycarbonate Block Copolymers
AU - Heo, Gyu Seong
AU - Cho, Sangho
AU - Wooley, Karen L.
N1 - Publisher Copyright:
© 2019, The Polymer Society of Korea and Springer.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - ABA-type polycarbonate block copolymers with pendant vinyl ether and benzyl functionalities were synthesized by sequential ring-opening polymerization of functional cyclic carbonate monomers using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organobase catalyst. The vinyl ether moieties on the resulting block copolymers were readily conjugated with 3-mercaptopropionic acid, cysteamine hydrochloride, and L-cysteine hydrochloride monohydrate through thiol-ene “click” reactions, yielding anionic, cationic, and zwitterionic self-assembled nanoparticles, respectively, in corresponding buffers. The effect of pH on the size and surface charge of nanoparticles were examined. [Figure not available: see fulltext.].
AB - ABA-type polycarbonate block copolymers with pendant vinyl ether and benzyl functionalities were synthesized by sequential ring-opening polymerization of functional cyclic carbonate monomers using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organobase catalyst. The vinyl ether moieties on the resulting block copolymers were readily conjugated with 3-mercaptopropionic acid, cysteamine hydrochloride, and L-cysteine hydrochloride monohydrate through thiol-ene “click” reactions, yielding anionic, cationic, and zwitterionic self-assembled nanoparticles, respectively, in corresponding buffers. The effect of pH on the size and surface charge of nanoparticles were examined. [Figure not available: see fulltext.].
KW - charged micelles
KW - click chemistry
KW - degradable polymeric nanoparticles
KW - polycarbonates
UR - http://www.scopus.com/inward/record.url?scp=85074430198&partnerID=8YFLogxK
U2 - 10.1007/s13233-020-8044-x
DO - 10.1007/s13233-020-8044-x
M3 - Article
AN - SCOPUS:85074430198
SN - 1598-5032
VL - 27
SP - 1173
EP - 1178
JO - Macromolecular Research
JF - Macromolecular Research
IS - 11
ER -