Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: Initial experience

Dongyang Zhang, James M. Johnston, Michael D. Fox, Eric C. Leuthardt, Robert L. Grubb, Michael R. Chicoine, Matthew D. Smyth, Abraham Z. Snyder, Marcus E. Raichle, Joshua S. Shimony

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

OBJECTIVE: To describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection. METHODS: Resting-state blood oxygenation-dependent functional magnetic resonance imaging (fMRI) scans were acquired in 17 healthy young adults and 4 patients with brain tumors invading sensorimotor cortex. Conventional fMRI motor mapping (finger-tapping protocol) was also performed in the patients. Intraoperatively, motor hand area was mapped using cortical stimulation. RESULTS: Robust and consistent delineation of sensorimotor cortex was obtained using the resting-state blood oxygenation-dependent data. Resting-state functional mapping localized sensorimotor areas consistent with cortical stimulation mapping and in all patients performed as well as or better than task-based fMRI. CONCLUSION: Resting-state correlation mapping is a promising tool for reliable functional localization of eloquent cortex. This method compares well with "gold standard" cortical stimulation mapping and offers several advantages compared with conventional motor mapping fMRI.

Original languageEnglish
Pages (from-to)ons226-ons236
JournalNeurosurgery
Volume65
Issue number6 SUPPL. 1
DOIs
StatePublished - Dec 1 2009

Keywords

  • Brain tumor
  • Functional magnetic resonance imaging
  • Resting state
  • Spontaneous fluctuations

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