Preoperative performance status predicts outcome following heated intraperitoneal chemotherapy

Nathaniel P. Reuter, Jay M. MacGregor, Charles E. Woodall, Robert P. Sticca, C. William, M. B. Helm, Charles R. Scoggins, Kelly M. McMasters, Robert C.G. Martin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Peritoneal carcinomatosis has a typical natural history of bowel obstruction and death. Significant evidence suggests that cytoreduction with heated intraperitoneal chemotherapy (HIPEC) improves long-term survival for these tumors. Methods: A retrospective case series of patients who underwent initial HIPEC treatment was performed at 2 moderate-volume centers. Clinicopathologic data were reviewed and univariate analyses performed to determine predictors of periprocedural complications. Results: Twenty-eight patients underwent HIPEC procedures. The most common pathologies were colonic adenocarcinoma and pseudomyxoma peritonei. The median preoperative peritoneal cancer index was 9.5. Thirteen patients had 34 complications, with no postoperative deaths. Pleural effusion and wound infection were the most common complications. Preoperative performance status and the extent of disease were predictive of complications. Conclusions: Cytoreduction and HIPEC can be done at moderate-volume centers with morbidity and mortality rates comparable with published results from large-volume centers. Preoperative performance status and the extent of disease predict postoperative complications.

Original languageEnglish
Pages (from-to)909-914
Number of pages6
JournalAmerican journal of surgery
Issue number6
StatePublished - Dec 2008


  • Complication
  • Cytoreduction
  • Heated intraperitoneal chemotherapy
  • Performance status
  • Peritoneal carcinomatosis


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