TY - JOUR
T1 - Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment
AU - Lin, Jonathan B.
AU - Sein, Julia
AU - Van Stavern, Gregory P.
AU - Apte, Rajendra S.
N1 - Funding Information:
J.B.L. was supported by the Washington University in St. Louis Medical Scientist Training Program (NIH Grant T32GM07200) and the Washington University in St. Louis Institute of Clinical and Translational Sciences (NIH Grants UL1TR002345, TL1TR002344). Additional funding comes from an unrestricted grant to the Department of Ophthalmology and Visual Sciences of Washington University School of Medicine from Research to Prevent Blindness.
Publisher Copyright:
© 2018 Medknow Publications.All Rights Reserved.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Purpose: To determine 1) which components of retinal function are impaired after rhegmatogenous retinal detachment, 2) which outer retinal pathways (rod- or cone-driven) are more severely affected, and 3) whether there is concomitant inner retinal dysfunction. Methods: We conducted a prospective observational study in a large academic institution. We performed preoperative electroretinography on eight patients to assess outer and inner retinal function. In all cases, a comparison between the eye with the detached retina and the control fellow eye was made. Results: Eyes with a detached retina had significantly lower a-wave and b-wave amplitudes with respect to both rod- and cone-dominated testing parameters (P < 0.05) and reduced 30 Hz flicker responses compared to fellow eyes (P < 0.05); the effect size was similar for all significantly reduced parameters (r~0.6). There were no significant differences between eyes with detached retinas and control fellow eyes with respect to b/a-wave ratios, a-wave latencies, or b-wave latencies. Conclusion: Patients with rhegmatogenous retinal detachment have preoperative outer retinal dysfunction equally affecting both rod- and cone-driven pathways, and they have minimal inner retinal dysfunction.
AB - Purpose: To determine 1) which components of retinal function are impaired after rhegmatogenous retinal detachment, 2) which outer retinal pathways (rod- or cone-driven) are more severely affected, and 3) whether there is concomitant inner retinal dysfunction. Methods: We conducted a prospective observational study in a large academic institution. We performed preoperative electroretinography on eight patients to assess outer and inner retinal function. In all cases, a comparison between the eye with the detached retina and the control fellow eye was made. Results: Eyes with a detached retina had significantly lower a-wave and b-wave amplitudes with respect to both rod- and cone-dominated testing parameters (P < 0.05) and reduced 30 Hz flicker responses compared to fellow eyes (P < 0.05); the effect size was similar for all significantly reduced parameters (r~0.6). There were no significant differences between eyes with detached retinas and control fellow eyes with respect to b/a-wave ratios, a-wave latencies, or b-wave latencies. Conclusion: Patients with rhegmatogenous retinal detachment have preoperative outer retinal dysfunction equally affecting both rod- and cone-driven pathways, and they have minimal inner retinal dysfunction.
KW - Clinical Electrophysiology
KW - Electroretinography
KW - Retinal Detachment
UR - http://www.scopus.com/inward/record.url?scp=85050265688&partnerID=8YFLogxK
U2 - 10.4103/jovr.jovr_161_17
DO - 10.4103/jovr.jovr_161_17
M3 - Article
C2 - 30090179
AN - SCOPUS:85050265688
SN - 2008-2010
VL - 13
SP - 241
EP - 248
JO - Journal of Ophthalmic and Vision Research
JF - Journal of Ophthalmic and Vision Research
IS - 3
ER -