Prenatal vitamin D supplementation to prevent childhood asthma: 15-year results from the Vitamin D Antenatal Asthma Reduction Trial (VDAART)

Scott T. Weiss, Hooman Mirzakhani, Vincent J. Carey, George T. O'Connor, Robert S. Zeiger, Leonard B. Bacharier, Jeffrey Stokes, Augusto A. Litonjua

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

This article provides an overview of the findings obtained from the Vitamin D Antenatal Asthma Reduction Trial (VDAART) spanning a period of 15 years. The review covers various aspects, including the trial's rationale, study design, and initial intent-to-treat analyses, as well as an explanation of why those analyses did not achieve statistical significance. Additionally, the article delves into the post hoc results obtained from stratified intent-to-treat analyses based on maternal vitamin D baseline levels and genotype-stratified analyses. These results demonstrate a statistically significant reduction in asthma among offspring aged 3 and 6 years when comparing vitamin D supplementation (4400 IU/d) to the standard prenatal multivitamin with vitamin D (400 IU/d). Furthermore, these post hoc analyses found that vitamin D supplementation led to a decrease in total serum IgE levels and improved lung function in children compared to those whose mothers received a placebo alongside the standard prenatal multivitamin with vitamin D. Last, the article concludes with recommendations regarding the optimal dosing of vitamin D for pregnant women to prevent childhood asthma as well as suggestions for future trials in this field.

Original languageEnglish
Pages (from-to)378-388
Number of pages11
JournalJournal of Allergy and Clinical Immunology
Volume153
Issue number2
DOIs
StatePublished - Feb 2024

Keywords

  • Vitamin D
  • childhood asthma
  • pregnancy
  • randomized trials
  • supplementation

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