TY - JOUR
T1 - Prenatal screening for thrombophilias
T2 - Indications and controversies
AU - Carbone, Jeanine F.
AU - Rampersad, Roxane
PY - 2010/9
Y1 - 2010/9
N2 - A thrombophilia is defined as a disorder of hemostasis that predisposes a person to a thrombotic event. Data suggest that at least 50% of cases of venous thromboembolism in pregnant women are associated with an inherited or acquired thrombophilia, which can lead to an increased risk of maternal thromboembolism and adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine fetal demise, preterm preeclampsia, and intrauterine growth restriction. Inherited and acquired thrombophilias have different indications for testing. This article examines screening procedures for thrombophilias in the setting of adverse pregnancy outcomes.
AB - A thrombophilia is defined as a disorder of hemostasis that predisposes a person to a thrombotic event. Data suggest that at least 50% of cases of venous thromboembolism in pregnant women are associated with an inherited or acquired thrombophilia, which can lead to an increased risk of maternal thromboembolism and adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine fetal demise, preterm preeclampsia, and intrauterine growth restriction. Inherited and acquired thrombophilias have different indications for testing. This article examines screening procedures for thrombophilias in the setting of adverse pregnancy outcomes.
KW - Acquired thrombophilia
KW - Inherited thrombophilia
KW - Pregnancy
KW - Thromboembolism
KW - Thrombophilia
KW - Venous
UR - http://www.scopus.com/inward/record.url?scp=77954769441&partnerID=8YFLogxK
U2 - 10.1016/j.cll.2010.05.003
DO - 10.1016/j.cll.2010.05.003
M3 - Review article
C2 - 20638586
AN - SCOPUS:77954769441
SN - 0272-2712
VL - 30
SP - 747
EP - 760
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
IS - 3
ER -