Prenatal prediction of lethal pulmonary hypoplasia using ultrasonic fetal chest circumference

Giuliana S. Songster, Diana L. Gray, James P. Crane

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Ultrasonic measurement of fetal chest circumference was tested as a predictor of pulmonary hypoplasia in a group of 26 fetuses at known risk. A 42% prevalence of autopsy-proved pulmonary hypoplasia was found in this population. Chest circumference measurements were plotted on published nomograms based upon head circumference, femur length, and gestational age. Longitudinal observations revealed a progressive lag in chest circumference growth among fetuses who proved to have pulmonary hypoplasia. The nomogram based on femur length provided sensitivity, specificity, and normal and abnormal predictive values of 80, 92, 92, and 89%, respectively. The results of this investigation suggest that fetal chest circumference measurement is a useful adjunct in establishing the diagnosis of lethal pulmonary hypoplasia.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalObstetrics and gynecology
Volume73
Issue number2
StatePublished - Feb 1989

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