TY - JOUR
T1 - Prenatal exposure to phthalates and male reproductive system development
T2 - Results from a Canadian pregnancy cohort study
AU - Romao, Rodrigo L.P.
AU - Dodds, Linda
AU - Ashley-Martin, Jillian
AU - Monnier, Patricia
AU - Arbuckle, Tye E.
N1 - Funding Information:
The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan.
Funding Information:
Male infants delivered by mothers participating in the Maternal-Infant Research on Environmental Chemicals Infant Development cohort (MIREC-ID) were assessed at birth. Details about the design of the MIREC Research Platform have been published elsewhere [ 22 ]. In summary, 1983 healthy pregnant women from 10 Canadian cities were recruited to participate from 2008 to 2011. Eligibility criteria included ability to communicate in English or French, age > 18 years, gestational age < 14 weeks. Ethics approval was obtained from Health Canada and participating sites. Women with significant medical conditions or carrying fetuses with major abnormalities were excluded. The study received funding from the Canadian Institute for Health Research and Health Canada.
Funding Information:
The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan.
Publisher Copyright:
© 2020
PY - 2020/8
Y1 - 2020/8
N2 - Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were measured shortly after birth in the male offspring. Univariate and multivariable linear regressions were performed to study associations between maternal phthalate exposure and penile measurements, adjusting for confounders. On univariate analysis of 170 mother-infant pairs, PW showed an inverse relationship with the concentration of mono-3-carboxypropyl phthalate (MCPP-p = 0.016), which was not confirmed on multivariable analysis. On multivariable analysis controlling for infant's size and other confounders, no statistically signficant associations between phthalate metabolite concentrations and PL or PW were identified. In this population of Canadian women, there was no strong evidence to suggest an association between maternal first trimester urinary phthalates with PL or PW in term singletons.
AB - Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were measured shortly after birth in the male offspring. Univariate and multivariable linear regressions were performed to study associations between maternal phthalate exposure and penile measurements, adjusting for confounders. On univariate analysis of 170 mother-infant pairs, PW showed an inverse relationship with the concentration of mono-3-carboxypropyl phthalate (MCPP-p = 0.016), which was not confirmed on multivariable analysis. On multivariable analysis controlling for infant's size and other confounders, no statistically signficant associations between phthalate metabolite concentrations and PL or PW were identified. In this population of Canadian women, there was no strong evidence to suggest an association between maternal first trimester urinary phthalates with PL or PW in term singletons.
KW - Endocrine disrupting chemicals
KW - Male genital development
KW - Penile length
KW - Penile width
KW - Phthalates
KW - Testicular dysgenesis syndrome
UR - https://www.scopus.com/pages/publications/85084491177
U2 - 10.1016/j.reprotox.2020.04.078
DO - 10.1016/j.reprotox.2020.04.078
M3 - Article
C2 - 32380128
AN - SCOPUS:85084491177
SN - 0890-6238
VL - 95
SP - 11
EP - 18
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -