TY - JOUR
T1 - Prenatal cannabis exposure, the brain, and psychopathology during early adolescence
AU - Baranger, David A.A.
AU - Miller, Alex P.
AU - Gorelik, Aaron J.
AU - Paul, Sarah E.
AU - Hatoum, Alexander S.
AU - Johnson, Emma
AU - Colbert, Sarah M.C.
AU - Smyser, Christopher D.
AU - Rogers, Cynthia
AU - Bijsterbosch, Janine D.
AU - Agrawal, Arpana
AU - Bogdan, Ryan
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
PY - 2024/8
Y1 - 2024/8
N2 - Prenatal cannabis exposure (PCE) is associated with mental health problems in early adolescence, but the possible neurobiological mechanisms remain unknown. In a large longitudinal sample of adolescents (ages 9–12 years, n = 9,322–10,186), we find that PCE is associated with localized differences in gray and white matter of the frontal and parietal cortices, their associated white matter tracts, and striatal resting-state connectivity, even after accounting for potential pregnancy, familial, and child confounds. Variability in forceps minor and pars triangularis diffusion metrics partially longitudinally mediate associations of PCE with attention problems and attention deficit hyperactivity disorder symptoms. PCE-related differences in brain development may confer vulnerability to worse mental health in early adolescence.
AB - Prenatal cannabis exposure (PCE) is associated with mental health problems in early adolescence, but the possible neurobiological mechanisms remain unknown. In a large longitudinal sample of adolescents (ages 9–12 years, n = 9,322–10,186), we find that PCE is associated with localized differences in gray and white matter of the frontal and parietal cortices, their associated white matter tracts, and striatal resting-state connectivity, even after accounting for potential pregnancy, familial, and child confounds. Variability in forceps minor and pars triangularis diffusion metrics partially longitudinally mediate associations of PCE with attention problems and attention deficit hyperactivity disorder symptoms. PCE-related differences in brain development may confer vulnerability to worse mental health in early adolescence.
UR - http://www.scopus.com/inward/record.url?scp=85205275327&partnerID=8YFLogxK
U2 - 10.1038/s44220-024-00281-7
DO - 10.1038/s44220-024-00281-7
M3 - Article
AN - SCOPUS:85205275327
SN - 2731-6076
VL - 2
SP - 975
EP - 986
JO - Nature Mental Health
JF - Nature Mental Health
IS - 8
M1 - 2613
ER -