Preliminary Study of Magnetic Resonance Imaging Characteristics in 8− to 16-Year-Olds with Mania

Kelly N. Botteron, Michael W. Vannier, Barbara Geller, Richard D. Todd, Benjamin C.P. Lee

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98 Scopus citations


To examine magnetic resonance imaging (MRI) characteristics in children and adolescents with mania according to DSM-III-R criteria. A convenience sample of consecutively referred 8− to 16-year-old manic (n = 10) and normal (n = 5) subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present Episode Version, the Children's Global Assessment Scale, and the Family History-Research Diagnostic Criteria. MRI scans were obtained from unsedated subjects using a 1.5 T MR scanner to acquire T1-weighted coronal and sagittal images and T2-welghted axial images. Images were assessed by blind clinical interpretation, ratings of T2-weighted deep white matter hyperintensities and petalia, and computer-assisted volumetric analysis of ventricular and cerebral volumes. Eight of 10 manic subjects and all 5 controls completed the scans. Scans of 4 manic subjects and 1 control subject showed ventricular or white matter abnormalities by clinical interpretation. Significant findings were positive correlations between increasing age and both right and left ventricular volumes. Two of the 8 manic subjects and no controls had confluent subcortical hyperintensities. Conclusions: MRI brain scanning was feasible in 8− to 16-year-olds. Preliminary findings from clinical interpretations and structured ratings suggest structural differences between young manic and normal subjects. Investigations of larger samples are needed to better characterize the differences. J. Am. Acad. Child Adolesc. Psychiatry, 1995, 34, 6:742–749.

Original languageEnglish
Pages (from-to)742-749
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Issue number6
StatePublished - 1995


  • adolescent
  • bipolar
  • brain
  • brain volume
  • child
  • lateral ventricles
  • magnetic resonance imaging
  • neurodevelopment
  • neuroimaging
  • neuromorphometry
  • petalia


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