Prekinamycin and an isosteric-isoelectronic analogue exhibit comparable cytotoxicity towards K562 human leukemia cells

Glenn L. Abbott; Xing Wu; Zhufeng Zhao; Lei Guo; Vladimir B. Birman; Brian B. Hasinoff; Gary I. Dmitrienko

doi:10.1039/c4md00197d

Prekinamycin and an isosteric-isoelectronic analogue exhibit comparable cytotoxicity towards K562 human leukemia cells

Glenn L. Abbott
, Xing Wu
, Zhufeng Zhao
, Lei Guo
, Vladimir B. Birman
, Brian B. Hasinoff
, Gary I. Dmitrienko

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The synthesis of N-cyanobenzo[b]carbazoloquinone 4, an isosteric- isoelectronic analogue of prekinamycin, is described. Cytotoxicity studies with K562 human leukemia cells reveal that the cyanamide analogue has a bioactivity profile similar to that of prekinamycin. These results indicate that the diazo functionality may not be an absolute requirement for bioactivity.

Original language	English
Pages (from-to)	1364-1370
Number of pages	7
Journal	MedChemComm
Volume	5
Issue number	9
DOIs	https://doi.org/10.1039/c4md00197d
State	Published - Sep 2014

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10.1039/c4md00197d

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title = "Prekinamycin and an isosteric-isoelectronic analogue exhibit comparable cytotoxicity towards K562 human leukemia cells",

abstract = "The synthesis of N-cyanobenzo[b]carbazoloquinone 4, an isosteric- isoelectronic analogue of prekinamycin, is described. Cytotoxicity studies with K562 human leukemia cells reveal that the cyanamide analogue has a bioactivity profile similar to that of prekinamycin. These results indicate that the diazo functionality may not be an absolute requirement for bioactivity.",

author = "Abbott, \{Glenn L.\} and Xing Wu and Zhufeng Zhao and Lei Guo and Birman, \{Vladimir B.\} and Hasinoff, \{Brian B.\} and Dmitrienko, \{Gary I.\}",

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T1 - Prekinamycin and an isosteric-isoelectronic analogue exhibit comparable cytotoxicity towards K562 human leukemia cells

AU - Abbott, Glenn L.

AU - Wu, Xing

AU - Zhao, Zhufeng

AU - Guo, Lei

AU - Birman, Vladimir B.

AU - Hasinoff, Brian B.

AU - Dmitrienko, Gary I.

PY - 2014/9

Y1 - 2014/9

N2 - The synthesis of N-cyanobenzo[b]carbazoloquinone 4, an isosteric- isoelectronic analogue of prekinamycin, is described. Cytotoxicity studies with K562 human leukemia cells reveal that the cyanamide analogue has a bioactivity profile similar to that of prekinamycin. These results indicate that the diazo functionality may not be an absolute requirement for bioactivity.

AB - The synthesis of N-cyanobenzo[b]carbazoloquinone 4, an isosteric- isoelectronic analogue of prekinamycin, is described. Cytotoxicity studies with K562 human leukemia cells reveal that the cyanamide analogue has a bioactivity profile similar to that of prekinamycin. These results indicate that the diazo functionality may not be an absolute requirement for bioactivity.

UR - https://www.scopus.com/pages/publications/84906546977

U2 - 10.1039/c4md00197d

DO - 10.1039/c4md00197d

M3 - Article

AN - SCOPUS:84906546977

SN - 2040-2503

VL - 5

SP - 1364

EP - 1370

JO - MedChemComm

JF - MedChemComm

IS - 9

ER -

Prekinamycin and an isosteric-isoelectronic analogue exhibit comparable cytotoxicity towards K562 human leukemia cells

Abstract

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