Pregnenolone sulfate and its enantiomer: Differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice

Géraldine H. Petit, Christine Tobin, Kathiresan Krishnan, Yves Moricard, Douglas F. Covey, Laure Rondi-Reig, Yvette Akwa

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14 Scopus citations

Abstract

This study examined the role of forebrain n-methyl-D-aspartate receptors (NMDA-Rs) in the promnesiant effects of natural (+) pregnenolone sulfate (PREGS) and its synthetic (-) enantiomer ent-PREGS in young adult mice. Using the two-trial arm discrimination task in a Y-maze, PREGS and ent-PREGS administration to control mice increased memory performances. In mice with a knock-out of the NR1 subunit of NMDA-Rs in the forebrain, the promnesiant effect of ent-PREGS was maintained whereas the activity of PREGS was lost. Memory enhancement by PREGS involves the NMDA-R activity in the hippocampal CA1 area and possibly in some locations of the cortical layers, whereas ent-PREGS acts independently of NMDA-R function.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalEuropean Neuropsychopharmacology
Volume21
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • Hippocampus
  • Memory
  • NMDA receptors
  • NR1 subunit
  • Pregnenolone sulfate
  • Steroid enantiomers
  • Y-maze

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