Pregnenolone sulfate and its enantiomer: Differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice

Géraldine H. Petit; Christine Tobin; Kathiresan Krishnan; Yves Moricard; Douglas F. Covey; Laure Rondi-Reig; Yvette Akwa

doi:10.1016/j.euroneuro.2010.09.010

Pregnenolone sulfate and its enantiomer: Differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice

Géraldine H. Petit, Christine Tobin, Kathiresan Krishnan, Yves Moricard, Douglas F. Covey, Laure Rondi-Reig, Yvette Akwa

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

This study examined the role of forebrain n-methyl-D-aspartate receptors (NMDA-Rs) in the promnesiant effects of natural (+) pregnenolone sulfate (PREGS) and its synthetic (-) enantiomer ent-PREGS in young adult mice. Using the two-trial arm discrimination task in a Y-maze, PREGS and ent-PREGS administration to control mice increased memory performances. In mice with a knock-out of the NR1 subunit of NMDA-Rs in the forebrain, the promnesiant effect of ent-PREGS was maintained whereas the activity of PREGS was lost. Memory enhancement by PREGS involves the NMDA-R activity in the hippocampal CA1 area and possibly in some locations of the cortical layers, whereas ent-PREGS acts independently of NMDA-R function.

Original language	English
Pages (from-to)	211-215
Number of pages	5
Journal	European Neuropsychopharmacology
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.euroneuro.2010.09.010
State	Published - Feb 2011

Keywords

Hippocampus
Memory
NMDA receptors
NR1 subunit
Pregnenolone sulfate
Steroid enantiomers
Y-maze

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10.1016/j.euroneuro.2010.09.010

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title = "Pregnenolone sulfate and its enantiomer: Differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice",

abstract = "This study examined the role of forebrain n-methyl-D-aspartate receptors (NMDA-Rs) in the promnesiant effects of natural (+) pregnenolone sulfate (PREGS) and its synthetic (-) enantiomer ent-PREGS in young adult mice. Using the two-trial arm discrimination task in a Y-maze, PREGS and ent-PREGS administration to control mice increased memory performances. In mice with a knock-out of the NR1 subunit of NMDA-Rs in the forebrain, the promnesiant effect of ent-PREGS was maintained whereas the activity of PREGS was lost. Memory enhancement by PREGS involves the NMDA-R activity in the hippocampal CA1 area and possibly in some locations of the cortical layers, whereas ent-PREGS acts independently of NMDA-R function.",

keywords = "Hippocampus, Memory, NMDA receptors, NR1 subunit, Pregnenolone sulfate, Steroid enantiomers, Y-maze",

author = "Petit, {G{\'e}raldine H.} and Christine Tobin and Kathiresan Krishnan and Yves Moricard and Covey, {Douglas F.} and Laure Rondi-Reig and Yvette Akwa",

note = "Funding Information: Funding of this study was provided in part by the Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale, GIS “Long{\'e}vit{\'e}” grants A04025LS (YA) and L0201 (LRR), Agence Nationale de la Recherche (ANR young Researcher 07-JCJC-0108-01) (LRR) and the United States National Institutes of Health grant GM 47969 (DFC). ",

year = "2011",

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doi = "10.1016/j.euroneuro.2010.09.010",

language = "English",

volume = "21",

pages = "211--215",

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AU - Krishnan, Kathiresan

AU - Moricard, Yves

AU - Covey, Douglas F.

AU - Rondi-Reig, Laure

AU - Akwa, Yvette

N1 - Funding Information: Funding of this study was provided in part by the Institut National de la Santé et de la Recherche Médicale, GIS “Longévité” grants A04025LS (YA) and L0201 (LRR), Agence Nationale de la Recherche (ANR young Researcher 07-JCJC-0108-01) (LRR) and the United States National Institutes of Health grant GM 47969 (DFC).

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KW - Memory

KW - NMDA receptors

KW - NR1 subunit

KW - Pregnenolone sulfate

KW - Steroid enantiomers

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Pregnenolone sulfate and its enantiomer: Differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice

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