Pregnancy in Marfan syndrome after aortic root replacement: A case report and review of the literature

Vania Volach, Amir Elami, Dan Gilon, Arthur Pollak, Yehuda Ginosar, Yossef Ezra

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective. Marfan syndrome is an inheritable connective tissue disorder with multisystem involvement and variable expression of signs and symptoms, caused by mutations within the fibrillin gene on chromosome 15q21. The reported incidence of severe cardiovascular events during pregnancy in Marfan patients' series is 3-7%, and the overall risk of fatal complication is approximately 1%. Although acute aortic dissection is a rare complication, an association between pregnancy and aortic dissection has been reported even in the absence of preconception aortic root dilatation. Design. Case report and literature review. Results. A 29-year-old pregnant woman with Marfan syndrome after replacement of ascending aorta with aortic valve conservation. She had a normal pregnancy and was delivered at term by cesarean section. Conclusion. Successful pregnancy and delivery can be achieved in Marfan's patients after aortic root replacement.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalCongenital Heart Disease
Volume1
Issue number4
DOIs
StatePublished - Jul 2006
Externally publishedYes

Keywords

  • Aortic root replacement
  • Marfan's
  • Pregnancy

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