TY - JOUR
T1 - Pregnancy and breastfeeding in the context of Ebola
T2 - a systematic review
AU - Foeller, Megan E.
AU - Carvalho Ribeiro do Valle, Carolina
AU - Foeller, Timothy M.
AU - Oladapo, Olufemi T.
AU - Roos, Elin
AU - Thorson, Anna E.
N1 - Funding Information:
We thank and acknowledge contributions to the design and execution of the search strategies from Sabina Gillsund and Magdalena Svanberg, librarians from the Karolinska Institutet Library, Stockholm, Sweden, and Tomas Allen, librarian from WHO. This research was funded by the UNDP/UN Populations Fund/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland. This Review represents the views of the named authors only. The funders of the study had no role in the study design, the extraction or interpretation of the data, the writing of the report, or the decision to submit the manuscript for publication. The corresponding author had full access to all data in the study and had the final responsibility for the decision to submit for publication. MEF and ER were contractors with WHO at the time of conduct of the study.
Funding Information:
We thank and acknowledge contributions to the design and execution of the search strategies from Sabina Gillsund and Magdalena Svanberg, librarians from the Karolinska Institutet Library, Stockholm, Sweden, and Tomas Allen, librarian from WHO. This research was funded by the UNDP/UN Populations Fund/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland. This Review represents the views of the named authors only. The funders of the study had no role in the study design, the extraction or interpretation of the data, the writing of the report, or the decision to submit the manuscript for publication. The corresponding author had full access to all data in the study and had the final responsibility for the decision to submit for publication. MEF and ER were contractors with WHO at the time of conduct of the study.
Publisher Copyright:
© 2020 World Health Organization. Published by Elsevier Ltd. All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - The outbreaks of Ebola virus between 2014 and 2020 have drawn attention to knowledge gaps related to Ebola virus disease in pregnant women. The aim of this study was to systematically evaluate available data on pregnant and lactating women with acute Ebola virus disease or following recovery. We searched MEDLINE, Embase, Cochrane Library (CENTRAL), Web of Science Core Collection, CINAHL, POPLINE, Global Health, and WHO Global Index Medicus, in addition to grey literature, for relevant articles. Studies of all types and published between database inception and Aug 19, 2019, were eligible (PROSPERO 129335). We identified 1060 records, of which 52 studies met our inclusion criteria. Overall, mortality in 274 pregnant women with Ebola virus disease was 72% (197 women died); mortality for pregnant women with Ebola virus disease were not higher than those in the general population of patients with Ebola virus disease. Nearly all women with Ebola virus disease had adverse pregnancy outcomes. Among survivors, Ebola virus RNA was detected by RT-PCR in amniotic fluid up to 32 days after maternal clearance of Ebola virus from the blood and in breastmilk 26 days after symptom onset. A risk of transmission of Ebola virus from pregnancy-related fluids and breastmilk probably exists, and precautions should be taken.
AB - The outbreaks of Ebola virus between 2014 and 2020 have drawn attention to knowledge gaps related to Ebola virus disease in pregnant women. The aim of this study was to systematically evaluate available data on pregnant and lactating women with acute Ebola virus disease or following recovery. We searched MEDLINE, Embase, Cochrane Library (CENTRAL), Web of Science Core Collection, CINAHL, POPLINE, Global Health, and WHO Global Index Medicus, in addition to grey literature, for relevant articles. Studies of all types and published between database inception and Aug 19, 2019, were eligible (PROSPERO 129335). We identified 1060 records, of which 52 studies met our inclusion criteria. Overall, mortality in 274 pregnant women with Ebola virus disease was 72% (197 women died); mortality for pregnant women with Ebola virus disease were not higher than those in the general population of patients with Ebola virus disease. Nearly all women with Ebola virus disease had adverse pregnancy outcomes. Among survivors, Ebola virus RNA was detected by RT-PCR in amniotic fluid up to 32 days after maternal clearance of Ebola virus from the blood and in breastmilk 26 days after symptom onset. A risk of transmission of Ebola virus from pregnancy-related fluids and breastmilk probably exists, and precautions should be taken.
UR - http://www.scopus.com/inward/record.url?scp=85084974813&partnerID=8YFLogxK
U2 - 10.1016/S1473-3099(20)30194-8
DO - 10.1016/S1473-3099(20)30194-8
M3 - Review article
C2 - 32595045
AN - SCOPUS:85084974813
SN - 1473-3099
VL - 20
SP - e149-e158
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
IS - 7
ER -