Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis

D. Grunberger, R. Banerjee, K. Eisinger, E. M. Oltz, L. Efros, M. Caldwell, V. Estevez, K. Nakanishi

Research output: Contribution to journalArticlepeer-review

464 Scopus citations

Abstract

The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE.

Original languageEnglish
Pages (from-to)230-232
Number of pages3
JournalExperientia
Volume44
Issue number3
DOIs
StatePublished - Mar 1988

Keywords

  • Honebee hive
  • caffeic acid ester
  • cytoxicity
  • propolis

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