Rats, in which carbachol reliably produced a polydipsia when micro-injected into the nucleus reuniens, preoptic region, septum or anterior hypothalamus, were simultaneously offered a forced choice of 4, 8 and 12% ethyl alcohol. Although these alcohol solutions were readily accepted by animals deprived of all fluids for 23 hr, these same rats totally rejected even normally preferred alcohol concentrations following a micro-injection of carbachol in any of these chemo-sensitive regions. Thus, it appears that cholinomimetic stimulation of structures in the so-called limbic system "thirst-circuit" does not evoke the same drinking response as that produced by fluid deprivation.
- Alcohol selection after cholinergic stimulation
- Brain stimulation with carbachol
- Carbachol and alcohol preference Cholinergic vs. natural thirst
- Chemical stimulation of brain
- Drinking patterns