TY - JOUR
T1 - Preference-aversion functions for alcohol after cholinergic stimulation of the brain and fluid deprivation
AU - Cicero, Theodore J.
AU - Myers, Robert D.
N1 - Funding Information:
Each rat was first tested for drinking following 23 hr fluid deprivation and then, following 2 days of ad iibitum food aThis research was supported in part by Grant GB7906 from the National Science Foundation and by a grant from the Wallace Laboratories. We are indebted to P. Curzon for his valuable technical assistance. IPresent address: Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, St. Louis, Missouri 63110.
PY - 1969/7
Y1 - 1969/7
N2 - Rats, in which carbachol reliably produced a polydipsia when micro-injected into the nucleus reuniens, preoptic region, septum or anterior hypothalamus, were simultaneously offered a forced choice of 4, 8 and 12% ethyl alcohol. Although these alcohol solutions were readily accepted by animals deprived of all fluids for 23 hr, these same rats totally rejected even normally preferred alcohol concentrations following a micro-injection of carbachol in any of these chemo-sensitive regions. Thus, it appears that cholinomimetic stimulation of structures in the so-called limbic system "thirst-circuit" does not evoke the same drinking response as that produced by fluid deprivation.
AB - Rats, in which carbachol reliably produced a polydipsia when micro-injected into the nucleus reuniens, preoptic region, septum or anterior hypothalamus, were simultaneously offered a forced choice of 4, 8 and 12% ethyl alcohol. Although these alcohol solutions were readily accepted by animals deprived of all fluids for 23 hr, these same rats totally rejected even normally preferred alcohol concentrations following a micro-injection of carbachol in any of these chemo-sensitive regions. Thus, it appears that cholinomimetic stimulation of structures in the so-called limbic system "thirst-circuit" does not evoke the same drinking response as that produced by fluid deprivation.
KW - Alcohol selection after cholinergic stimulation
KW - Brain stimulation with carbachol
KW - Carbachol and alcohol preference Cholinergic vs. natural thirst
KW - Chemical stimulation of brain
KW - Drinking patterns
UR - http://www.scopus.com/inward/record.url?scp=50849151598&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(69)90154-1
DO - 10.1016/0031-9384(69)90154-1
M3 - Article
AN - SCOPUS:50849151598
SN - 0031-9384
VL - 4
SP - 559-560,IN13-IN14,561-562
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 4
ER -