@article{51c1e21aa81948d69c06cef6d239b40a,
title = "Predominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials",
abstract = "Purpose: To describe predominantly persistent intraretinal fluid (PP-IRF) and its association with visual acuity (VA) and retinal anatomic findings at long-term follow-up in eyes treated with pro re nata (PRN) ranibizumab or bevacizumab for neovascular age-related macular degeneration. Design: Cohort within a randomized clinical trial. Participants: Participants in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT) assigned to PRN treatment. Methods: The presence of intraretinal fluid (IRF) on OCT scans was assessed at baseline and monthly follow-up visits by Duke OCT Reading Center. Predominantly persistent intraretinal fluid through week 12, year 1, and year 2 was defined as the presence of IRF at the baseline and in ≥ 80% of follow-up visits. Among eyes with baseline IRF, the mean VA scores (letters) and changes from the baseline were compared between eyes with and those without PP-IRF. Adjusted mean VA scores and changes from the baseline were also calculated using the linear regression analysis to account for baseline patient features identified as predictors of VA in previous CATT studies. Furthermore, outcomes were adjusted for concomitant predominantly persistent subretinal fluid. Main Outcome Measures: Predominantly persistent intraretinal fluid through week 12, year 1, and year 2; VA score and VA change; and scar development at year 2. Results: Among 363 eyes with baseline IRF, 108 (29.8%) had PP-IRF through year 1 and 95 (26.1%) had PP-IRF through year 2. When eyes with PP-IRF through year 1 were compared with those without PP-IRF, the mean 1-year VA score was 62.4 and 68.5, respectively (P = 0.002), and was 65.0 and 67.4, respectively (P = 0.13), after adjustment. Predominantly persistent intraretinal fluid through year 2 was associated with worse adjusted 1-year mean VA scores (64.8 vs. 69.2; P = 0.006) and change (4.3 vs. 8.1; P = 0.01) as well as worse adjusted 2-year mean VA scores (63.0 vs. 68.3; P = 0.004) and changes (2.4 vs. 7.1; P = 0.009). Predominantly persistent intraretinal fluid through year 2 was associated with a higher 2-year risk of scar development (adjusted hazard ratio = 1.49; P = 0.03). Conclusions: Approximately one quarter of eyes had PP-IRF through year 2. Predominantly persistent intraretinal fluid through year 1 was associated with worse long-term VA, but the relationship disappeared after adjustment for baseline predictors of VA. Predominantly persistent intraretinal fluid through year 2 was independently associated with worse long-term VA and scar development.",
keywords = "Anti-VEGF, Choroidal neovascularization, Intraretinal fluid, Persistent, Visual acuity",
author = "{Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group} and Core, {Jason Q.} and Maxwell Pistilli and Peiying Hua and Ebenezer Daniel and Grunwald, {Juan E.} and Toth, {Cynthia A.} and Jaffe, {Glenn J.} and Martin, {Daniel F.} and Maguire, {Maureen G.} and Ying, {Gui Shuang} and Williams, {David F.} and Sara Beardsley and Steven Bennett and Herbert Cantrill and Carmen Chan-Tram and Holly Cheshier and John Davies and Sundeep Dev and Julianne Enloe and Gennaro Follano and Peggy Gilbert and Jill Johnson and Tori Jones and Lisa Mayleben and Robert Mittra and Martha Moos and Ryan Neist and Neal Oestreich and Polly Quiram and Robert Ramsay and Edwin Ryan and Stephanie Schindeldecker and Trenise Steele and Jessica Tonsfeldt and Shelly Valardi and Fish, {Gary Edd} and Aguado, {Hank A.} and Sally Arceneaux and Jean Arnwine and Kim Bell and Tina Bell and Bob Boleman and Patricia Bradley and David Callanan and Lori Coors and Jodi Creighton and Kimberly Cummings and Christopher Dock and Karen Duignan and Dwain Fuller and Keith Gray and Betsy Hendrix and Nicholas Hesse and Diana Jaramillo and Bradley Jost and Sandy Lash and Laura Lonsdale and Michael Mackens and Karin Mutz and Michael Potts and Brenda Sanchez and William Snyder and Wayne Solley and Carrie Tarter and Robert Wang and Patrick Williams and Perkins, {Stephen L.} and Nicholas Anderson and Ann Arnold and Paul Blais and Joseph Googe and Higdon, {Tina T.} and Cecile Hunt and Mary Johnson and James Miller and Misty Moore and Morris, {Charity K.} and Christopher Morris and Sarah Oelrich and Kristina Oliver and Vicky Seitz and Jerry Whetstone and Doft, {Bernard H.} and Jay Bedel and Robert Bergren and Ann Borthwick and Paul Conrad and Christina Fulwylie and Willia Ingram and Shawnique Latham and Gina Lester and Judy Liu and Louis Lobes and Lucko, {Nicole M.} and Lori Merlotti and Karl Olsen and Danielle Puskas and Pamela Rath and Lynn Schueckler and Christina Schultz and Heather Shultz and David Steinberg and Avni Vyas and Kim Whale and Kimberly Yeckel and Orth, {David H.} and Arredondo, {Linda S.} and Susan Brown and Ciscato, {Barbara J.} and Civantos, {Joseph M.} and Celeste Figliulo and Sohail Hasan and Belinda Kosinski and Dan Muir and Kiersten Nelson and Kirk Packo and Pollack, {John S.} and Kourous Rezaei and Gina Shelton and Shannya Townsend-Patrick and Marian Walsh and {Richard McDonald}, H. and Nina Ansari and Amanda Bye and Fu, {Arthur D.} and Sean Grout and Chad Indermill and Johnson, {Robert N.} and Jumper, {J. Michael} and Silvia Linares and Lujan, {Brandon J.} and Ames Munden and Rosa Rodriguez and Rose, {Jennifer M.} and Brandi Teske and Yesmin Urias and Stephen Young and Dreyer, {Richard F.} and Howard Daniel and Michele Connaughton and Irvin Handelman and Stephen Hobbs and Christine Hoerner and Dawn Hudson and Marcia Kopfer and Michael Lee and Craig Lemley and Joe Logan and Colin Ma and Christophe Mallet and Amanda Milliron and Mark Peters and Harry Wohlsein and Pearlman, {Joel A.} and Margo Andrews and Melissa Bartlett and Nanette Carlson and Emily Cox and Robert Equi and Marta Gonzalez and Sophia Griffin and Fran Hogue and Lance Kennedy and Lana Kryuchkov and Carmen Lopez and Danny Lopez and Bertha Luevano and Erin McKenna and Arun Patel and Brian Reed and Nyla Secor and Sison, {Iris R.} and Tony Tsai and Nina Varghis and Brooke Waller and Robert Wendel and Reina Yebra and Roth, {Daniel B.} and Jane Deinzer and Howard Fine and Flory Green and Stuart Green and Bruce Keyser and Steven Leff and Amy Leviton and Amy Martir and Kristin Mosenthine and Starr Muscle and Linda Okoren and Sandy Parker and Jonathan Prenner and Nancy Price and Deana Rogers and Linda Rosas and Alex Schlosser and Loretta Studenko and Thea Tantum and Harold Wheatley and Trese, {Michael T.} and Rao, {P. Kumar}",
note = "Publisher Copyright: {\textcopyright} 2022 American Academy of Ophthalmology",
year = "2022",
month = sep,
doi = "10.1016/j.oret.2022.03.024",
language = "English",
volume = "6",
pages = "771--785",
journal = "Ophthalmology Retina",
issn = "2468-6530",
number = "9",
}