TY - JOUR
T1 - Predictors of stability of attention-deficit/hyperactivity disorder subtypes from childhood to young adulthood
AU - Todd, Richard D.
AU - Huang, Hongyan
AU - Todorov, Alexandre A.
AU - Neuman, Rosalind J.
AU - Reiersen, Angela M.
AU - Henderson, Cynthia A.
AU - Reich, Wendy C.
PY - 2008/1
Y1 - 2008/1
N2 - OBJECTIVE: To determine the 5-year prospective stability of population-based and DSM-IV subtypes of attention-deficit/hyperactivity disorder (ADHD) as well as to explore predictors of stability. METHOD: A total of 708 twins ages 7 to 19 years who were identified from birth records of the state of Missouri and had participated in a study of ADHD were reassessed 5 years later in a blinded fashion. Stabilities of DSM-IV and population-based ADHD subtypes were compared using percentage of agreement with significance tested by the κ statistic. Predictors of stability of subtype diagnosis were determined using multivariate logistic regression. RESULTS: In general, 5-year ADHD subtype stability was poor to modest and ranged from 11.1% to 24.0% for DSM-IV for subtypes and from 14.3% to 35.3% for clinically significant population-derived subtypes. There were no predictors of diagnostic stability that applied across subtypes. There were subtype-specific predictors including a diagnosis of oppositional defiant disorder for DSM-IV primarily inattentive ADHD; lower verbal IQ for DSM-IV combined type ADHD; and younger age, oppositional defiant disorder, and medication use for population-defined severe combined ADHD. CONCLUSIONS: Population-defined ADHD subtype criteria demonstrated modestly improved diagnostic stability over 5 years compared to DSM-IV subtypes. Few correlates or predictors of stability were identified. Copyright 2008
AB - OBJECTIVE: To determine the 5-year prospective stability of population-based and DSM-IV subtypes of attention-deficit/hyperactivity disorder (ADHD) as well as to explore predictors of stability. METHOD: A total of 708 twins ages 7 to 19 years who were identified from birth records of the state of Missouri and had participated in a study of ADHD were reassessed 5 years later in a blinded fashion. Stabilities of DSM-IV and population-based ADHD subtypes were compared using percentage of agreement with significance tested by the κ statistic. Predictors of stability of subtype diagnosis were determined using multivariate logistic regression. RESULTS: In general, 5-year ADHD subtype stability was poor to modest and ranged from 11.1% to 24.0% for DSM-IV for subtypes and from 14.3% to 35.3% for clinically significant population-derived subtypes. There were no predictors of diagnostic stability that applied across subtypes. There were subtype-specific predictors including a diagnosis of oppositional defiant disorder for DSM-IV primarily inattentive ADHD; lower verbal IQ for DSM-IV combined type ADHD; and younger age, oppositional defiant disorder, and medication use for population-defined severe combined ADHD. CONCLUSIONS: Population-defined ADHD subtype criteria demonstrated modestly improved diagnostic stability over 5 years compared to DSM-IV subtypes. Few correlates or predictors of stability were identified. Copyright 2008
KW - Attention-deficit/hyperactivity disorder
KW - Development
KW - Twin study
UR - http://www.scopus.com/inward/record.url?scp=38049086882&partnerID=8YFLogxK
U2 - 10.1097/chi.0b013e31815a6aca
DO - 10.1097/chi.0b013e31815a6aca
M3 - Article
C2 - 18174828
AN - SCOPUS:38049086882
SN - 0890-8567
VL - 47
SP - 76
EP - 85
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 1
ER -