Predictors of Relapse in Major Depressive Disorder

Martin B. Keller, Philip W. Lavori, Collins E. Lewis, Gerald L. Klerman

Research output: Contribution to journalArticlepeer-review

267 Scopus citations


Risk of relapse into an affective episode was high in the months immediately after recovery from a major depressive disorder (MDD) in 141 subjects with nonbipolar depression, without a preexisting dysthymic disorder. The probability of relapse then declined steadily during the duration of the follow-up (median follow-up, 62 weeks from recovery). In patients entering the study during their first affective episode, the Research Diagnostic Criteria secondary subtype of MDD and an older age of onset predicted a significantly greater likelihood of relapse. Three or more prior episodes of depression predicted a significantly shorter time to the first and second prospectively observed relapses and, thus, a significantly greater likelihood of subsequent multiple affective episodes.

Original languageEnglish
Pages (from-to)3299-3304
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Issue number24
StatePublished - Dec 23 1983


Dive into the research topics of 'Predictors of Relapse in Major Depressive Disorder'. Together they form a unique fingerprint.

Cite this