TY - JOUR
T1 - Predictors of Relapse in Major Depressive Disorder
AU - Keller, Martin B.
AU - Lavori, Philip W.
AU - Lewis, Collins E.
AU - Klerman, Gerald L.
PY - 1983/12/23
Y1 - 1983/12/23
N2 - Risk of relapse into an affective episode was high in the months immediately after recovery from a major depressive disorder (MDD) in 141 subjects with nonbipolar depression, without a preexisting dysthymic disorder. The probability of relapse then declined steadily during the duration of the follow-up (median follow-up, 62 weeks from recovery). In patients entering the study during their first affective episode, the Research Diagnostic Criteria secondary subtype of MDD and an older age of onset predicted a significantly greater likelihood of relapse. Three or more prior episodes of depression predicted a significantly shorter time to the first and second prospectively observed relapses and, thus, a significantly greater likelihood of subsequent multiple affective episodes.
AB - Risk of relapse into an affective episode was high in the months immediately after recovery from a major depressive disorder (MDD) in 141 subjects with nonbipolar depression, without a preexisting dysthymic disorder. The probability of relapse then declined steadily during the duration of the follow-up (median follow-up, 62 weeks from recovery). In patients entering the study during their first affective episode, the Research Diagnostic Criteria secondary subtype of MDD and an older age of onset predicted a significantly greater likelihood of relapse. Three or more prior episodes of depression predicted a significantly shorter time to the first and second prospectively observed relapses and, thus, a significantly greater likelihood of subsequent multiple affective episodes.
UR - http://www.scopus.com/inward/record.url?scp=0021020192&partnerID=8YFLogxK
U2 - 10.1001/jama.1983.03340240025024
DO - 10.1001/jama.1983.03340240025024
M3 - Article
C2 - 6645026
AN - SCOPUS:0021020192
SN - 0098-7484
VL - 250
SP - 3299
EP - 3304
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 24
ER -