Predictors of poor weight gain in infants with a single ventricle

Jeffrey B. Anderson, Robert H. Beekman, Pirooz Eghtesady, Heidi J. Kalkwarf, Karen Uzark, Jack E. Kehl, Bradley S. Marino

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Objective: To assess growth from the time of neonatal discharge to the time of performance of the bidirectional Glenn (BDG) procedure in infants with a single ventricle and determine predictors of poor growth. Study design: We performed a retrospective case series of infants who underwent the BDG procedure at our institution between January 2001 and December 2007 (n = 102). Anthropometric and clinical data were recorded during neonatal hospitalization and before BDG. Outcome variables included weight-for-age z-score (WAZ) at the time of BDG and average daily weight gain between neonatal discharge and BDG. Results: Median age at the time of BDG was 5.1 months (range, 2.4-10 months), and median WAZ was -0.4 (range, -2.6 to 3.2) at neonatal admission and -1.3 (range, -3.9 to 0.6) at the time of BDG. Non-Caucasian infants (P = .03) and those with lower WAZ at neonatal discharge (P <.0001) had a lower WAZ at BDG. Being formula-fed at neonatal discharge (P = .04), and having higher mean pulmonary arterial pressure (P = .04) and systemic oxygen saturation (P = .006) were associated with lower average daily weight gain between neonatal discharge and BDG. Conclusions: Infants with a single ventricle have poor weight gain between neonatal discharge and BDG. Non-Caucasian infants and those with evidence of increased pulmonary blood flow are at particular risk for growth failure.

Original languageEnglish
Pages (from-to)407-413+413.e1
JournalJournal of Pediatrics
Volume157
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • BDG
  • BTS
  • Bidirectional Glenn
  • Blalock-Taussig shunt
  • CCHMC
  • CDC
  • CHD
  • Centers for Disease Control and Prevention
  • Cincinnati Children's Hospital Medical Center
  • Congenital heart disease
  • FTT
  • Failure to thrive
  • HLHS
  • Hypoplastic left heart syndrome
  • NEC
  • NG
  • Nasogastric
  • Necrotizing enterocolitis
  • PVR
  • Pulmonary vascular resistance
  • SGA
  • Small for gestational age
  • WAZ
  • Weight-for-age z-score

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  • Cite this

    Anderson, J. B., Beekman, R. H., Eghtesady, P., Kalkwarf, H. J., Uzark, K., Kehl, J. E., & Marino, B. S. (2010). Predictors of poor weight gain in infants with a single ventricle. Journal of Pediatrics, 157(3), 407-413+413.e1. https://doi.org/10.1016/j.jpeds.2010.04.012