Predictors of oral anticoagulant non-prescription in patients with atrial fibrillation and elevated stroke risk

Steven A. Lubitz, Shaan Khurshid, Lu Chen Weng, Gheorghe Doros, Joseph Walker Keach, Qi Gao, Anil K. Gehi, Jonathan C. Hsu, Matthew R. Reynolds, Mintu P. Turakhia, Thomas M. Maddox

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background: Many patients with atrial fibrillation (AF) and elevated stroke risk are not prescribed oral anticoagulation (OAC) despite evidence of benefit. Identification of factors associated with OAC non-prescription could lead to improvements in care. Methods and Results: Using NCDR PINNACLE, a United States-based ambulatory cardiology registry, we examined factors associated with OAC non-prescription in patients with non-valvular AF at elevated stroke risk (CHA 2 DS 2 -VASc ≥2) between January 5, 2008 and December 31, 2014. Among 674,841 patients, 57% were treated with OAC (67% of whom were treated with warfarin). OAC prescription varied widely (28%-75%) across preselected strata of age, stroke risk (CHA 2 DS 2 -VASc), and bleeding risk (HAS-BLED), generally indicating that older patients at high stroke and low bleeding risk are commonly treated with OAC. Other factors associated with OAC non-prescription included reversible AF etiology; female sex; liver, renal, or vascular disease; and physician versus non-physician provider. Antiplatelet use was common (57%) and associated with the greatest risk of OAC non-prescription (odds ratio [OR] 4.44, 95% confidence interval [CI] 4.39–4.49). Conclusions: In this registry of AF patients, older patients at elevated stroke and low bleeding risk were commonly treated with OAC. However, a variety of factors were associated with OAC non-prescription. Specifically, antiplatelet use was prevalent and associated with the highest likelihood of OAC non-prescription. Future studies are warranted to understand provider and patient rationale that may underlie observed associations with OAC non-prescription.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalAmerican heart journal
Volume200
DOIs
StatePublished - Jun 2018

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